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Found 95 clinical trials
Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS) (PATHOS)

The main objectives of the PATHOS study are: To assess whether swallowing function can be improved following transoral resection of HPV-positive OPSCC, by reducing the intensity of adjuvant treatment protocols. The aim is to personalise treatment, based on disease biology (HPV status and pathology findings), to optimise patient outcomes. To …

  • 49 views
  • 23 May, 2022
  • 38 locations
A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients With Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer

oropharyngeal cancer that is early in its growth and may not have spread to other parts of the body (early-stage), and is not associated with smoking. Radiation therapy uses high-energy x-rays to kill tumor

measurable disease
administration intravenous
oropharyngeal
ct scan
nivolumab
  • 196 views
  • 21 Oct, 2022
  • 226 locations
A Phase III Randomized Study of Maintenance Nivolumab Versus Observation in Patients With Locally Advanced, Intermediate Risk HPV Positive OPSCC

overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer

  • 437 views
  • 23 Oct, 2022
  • 461 locations
  • 1 views
  • 23 Oct, 2022
  • 7 locations
A Randomized, Double-blind, Placebo-Controlled, Phase 2 Study of Cemiplimab Versus the Combination of Cemiplimab With ISA101b in the Treatment of Subjects With HPV16-Positive Oropharyngeal Cancer (OPC)

This will be a blinded, placebo-controlled, randomized, phase 2 study in which subjects will be randomly assigned 1:1 to cemiplimab plus placebo or cemiplimab plus ISA101b.

ct scan
measurable disease
isa101b
treatment schedule
  • 25 views
  • 18 Oct, 2022
  • 59 locations
Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"

The main goal of this phase of the study is to determine if objectively assessed Physical Activity (PA) levels in advanced-cancer patients are associated with health care provider (HCP)-assessed ECOG performance status and overall survival. The purpose is to advance the evidence-base for incorporating objective assessment of Physical Activity (PA) …

radiation oncology
adenocarcinoma
advanced cancer
neuroendocrine tumor
cancer
  • 43 views
  • 03 Jun, 2022
  • 1 location
A Trial Evaluating the Addition of Nivolumab to Cisplatin-RT for Treatment of Cancers of the Head and Neck (NIVOPOSTOP)

The purpose of this study is to determine the efficacy of nivolumab + cisplatin-RT relative to standard of care (SOC) cisplatin-RT alone, using the disease-free survival (DFS by investigator imaging assessment) as primary endpoint )

caries
cavities
hyperhydration
cancer
head and neck carcinoma
  • 5 views
  • 14 Apr, 2022
  • 1 location
Adaptive RadioTherapy for OroPharynx Cancer

This is a phase II randomized trial, where patients with histologically proven squamous cell carcinoma of oropharynx that have primary tumor (T3 - T4) in place, treated with curative intent

  • 0 views
  • 13 Aug, 2021
  • 1 location
  • 0 views
  • 04 Oct, 2022
  • 1 location
Study of Lymphatic Drainage Mapping in Oropharyngeal Cancers

The purpose of the study is to see how practical it is to inject a radiotracer called 99m-Technetium Sulfur Colloid around the tumors for the imaging of patients with oropharyngeal cancer.

  • 0 views
  • 01 Oct, 2021
  • 1 location