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Found 172 clinical trials
Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC

Sometimes, cancer patients receive an initial treatment, followed by additional treatment to lower the chance of cancer coming back. The standard or usual treatment for this type of disease is initially having radiation therapy at the same time as chemotherapy (with a drug called cisplatin), with no additional therapy afterwards

treatment schedule
oropharyngeal carcinoma
neutrophil count
human papillomavirus
durvalumab
  • 56 views
  • 17 Jan, 2021
  • 30 locations
Pneumocystis Pneumonia Diagnosis in HIV- Patients

Pneumocystis Polymerase Chain Reaction, to guide the management of optimal patient. In this work, the investigators propose to evaluate the Polymerase Chain Reaction on oropharyngeal rinse, non

mechanical ventilation
pneumonia
corticosteroids
AIDS
cytostatics
  • 3 views
  • 24 Jan, 2021
  • 3 locations
Transmission Reduction and Prevention With HPV Vaccination (TRAP-HPV) Study

Human papillomavirus (HPV) is a member of the Papillomaviridae family of DNA viruses that is capable of infecting humans. HPV infection can cause cancers of the cervix, vulva, vagina, and anus in women or cancers of the anus and penis in men. Two prophylactic vaccines have been proven to be …

hpv vaccine
gardasil
vaccination
human papillomavirus
cancer
  • 9 views
  • 04 Nov, 2020
  • 1 location
Pilot Study of Chemotherapy for HPV-Associated Oropharyngeal Cancer

Doctors leading this study will give blood tests to head and neck cancer participants during the beginning of chemotherapy treatment (also known as induction therapy) to see if these blood tests can help predict tumor shrinkage after therapy and reduce the amount of additional radiotherapy or chemotherapy treatment the participant …

  • 0 views
  • 05 Nov, 2020
  • 1 location
Primary Radiotherapy Versus Primary Surgery for HPV-Associated Oropharyngeal Cancer

The goal of this randomized treatment de-escalation study is to formally compare outcomes in HPV related oropharyngeal cancer tumors treated with a primary radiotherapy versus a primary surgical

neck dissection
anesthesia
squamous cell carcinoma
neutrophil count
primary tumor
  • 18 views
  • 24 Jan, 2021
  • 11 locations
Feasibility and Tolerance of Nivolumab Neoadjuvant Immunotherapy in High Risk HPV Driven Oropharynx Cancer

The aim of this research is to study the feasibility of neoadjuvant treatment before chemoradiation in "high risk" HPV-driven Oropharynx cancer

nivolumab
oropharyngeal squamous cell carcinoma
chemoradiotherapy
immunohistochemistry
squamous cell carcinoma
  • 1 views
  • 24 Jan, 2021
  • 11 locations
Anti-EGFR Therapy With IMRT Concurrent Chemoradiotherapy in Locally Advanced OPC With Induced Chemotherapy Resistance

advanced oropharyngeal carcinoma (OPC) with induced chemotherapy resistance. Eligibility criteria include histologically confirmed locally advanced OPC according to the American Joint Committee on

induction chemotherapy
chemoradiotherapy
EGFR
intensity-modulated radiation therapy
metastasis
  • 0 views
  • 24 Jan, 2021
  • 1 location
Analgesia of Fibula Free Flap Donor Site by Peri-Neuronal Catheter in Oro-Pharyngeal Carcinoma Surgery

This trial examines the analgesia of the fibula free flap donor site by peri-neuronal catheter in oro-pharyngeal carcinoma surgery by comparing continuous infusion of a local anesthetic with systemic multimodal analgesia.

  • 6 views
  • 07 Nov, 2020
  • 1 location
Cetuximab & Concomitant-Boost Accelerated RT in Patients With Locally Advanced Oropharynx Squamous Cell Carcinoma.

The purpose of this study is to determine the 1-year rate of locoregional disease control in the experimental arm, using a control arm to avoid selection bias.

  • 15 views
  • 07 Nov, 2020
  • 1 location
Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx Cancer

This prospective study aims to utilize pre- and mid-treatment PET-CT to guide de-escalation of radiation therapy in HPV-related squamous cell carcinoma of the oropharynx.

oropharyngeal squamous cell carcinoma
squamous cell carcinoma
immunohistochemistry
avid
oropharyngeal carcinoma
  • 5 views
  • 17 Jan, 2021
  • 2 locations