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Found 273 clinical trials
Featured trial
Safety and Efficacy of Itacitinib in Participants With Bronchiolitis Obliterans Syndrome Following Lung Transplantation

The purpose of this study is to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of itacitinib in participants with post-lung transplant bronchiolitis obliterans syndrome (BOS).  

bronchiolitis obliterans
organ transplantation
lung transplant
  • 10 May, 2022
  • 7 locations
Featured trial
Do you suffer from Hemorrhoids?

Do you suffer from Hemorrhoids?

  • 25 Mar, 2021
  • 1 location
Azole-echinocandin Combination Therapy for Invasive Aspergillosis

The goals of this study are 3-fold: First, the main study and the primary endpoint will evaluate if the overall mortality can be decreased with initial azole-echinocandin combination therapy compared with triazole monotherapy in patients with IA and documented voriconazole susceptibility. Second, the study design described will also allow to …

  • 16 Oct, 2021
  • 4 locations
Optimizing Long-term Survival in Organ Transplantation: From Physiopathology to Optimized Patient Management

University Hospital Federation (UHF) "SUPORT" was created to optimize the chances of success of the organ transplant and improve the quality of life of the transplanted patient. UHF SUPORT 's ambition is

heart transplant
  • 21 Oct, 2021
  • 3 locations
Fecal Microbiota Transplantation for C. Difficile Infection in Solid Organ Transplant Recipients

The objective is to examine the effect of Fecal Microbiota Transplantation (FMT) compared with vancomycin for cure of recurrent C. diff infection (CDI) in solid organ transplant (SOT) recipients

  • 27 Apr, 2022
  • 1 location
A Study to Evaluate Safety and Immunogenicity of mRNA-1273 Vaccine to Prevent COVID-19 in Adult Organ Transplant Recipients and in Healthy Adult Participants

liver solid organ transplant (SOT) and in healthy adult participants. The primary goal of the study is to evaluate the safety of mRNA-1273 and the serum antibody (Ab) responses obtained 28 days after

Accepts healthy volunteers
  • 14 Apr, 2022
  • 1 location
Using T-Cell Alloreactivity and Chimerism to Guide Immunosuppression Minimization in Intestinal Transplantation

with the high levels of immunosuppression medication(s) that intestinal and multi-organ transplant patients must take. Infusion of bone marrow cells from the same donor of the transplanted organ(s

  • 05 Jan, 2022
SARS-CoV-2 CTLS for Mild to Moderate COVID-19 Disease

become an important part of the treatment landscape for viral reactivation post hematopoietic and solid organ transplantation. Donor derived CTLs have been shown to be safe and effective against a

  • 24 Mar, 2022
  • 1 location
Efficiency of Everolimus for the Treatment of Kidney Transplanted Patients Presenting a Missing Self-induced NK-mediated Rejection (STARR)

Background Long-term success of organ transplantation is limited by the inexorable loss of graft function due to rejection. Prevalent dogma defends that allograft

Accepts healthy volunteers
  • 25 May, 2022
The Effects of Tranexamic Acid or Placebo on Perioperative Bleeding in Adults Undergoing Liver Transplantation.

Around 230 million major procedures are performed worldwide each year. Postoperative complications after major surgery, especially in solid organ transplants, are associated with a significant

venous thromboembolism
surgical blood loss
tranexamic acid
  • 02 Sep, 2021
  • 1 location