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Found 222 clinical trials
Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensive, and frequently lethal condition

  • 24 Jan, 2021
  • 1 location
Catalysing the Containment of COVID-19

properties, and (iv) minimise disease progression to hospitalisation thus circumventing the 'cytokine storm' that likely underpins ARDS and multi-organ failure. Nitazoxanide (NTZ) is an antiprotozoal

organ failure
antihypertensive drugs
ebola virus disease
  • 11 Apr, 2021
  • 4 locations
Antibioprophylaxis for Excision-graft Surgery in Burn Patient (A2B-TRIAL)

The indication of antibiotic prophylaxis in burn patients remains highly controversial and hasn't reached a consensus. The objective of antibiotic prophylaxis would be to reduce the risk of post-operative local and systemic infections. Burn surgery is associated with a high risk of bacteremia and postoperative infections and sepsis. However, antibiotic …

  • 26 Jan, 2021
  • 1 location
Endotracheal Tubes to Prevent Ventilator-Associated Pneumonia

Researchers are looking at two different types of breathing tubes to see if one is better than the other at preventing pneumonia. One of the tubes has a design features to prevent leakage of fluids from the mouth and the back of the throat into the lower airways and lungs. …

  • 26 Jan, 2021
  • 2 locations
Vitamin D Omega-3 and Combination Vitamins B C and Zinc Supplementation for the Treatment and Prevention of COVID-19

We will conduct randomized, double-blind, placebo-controlled, 2x2x2 factorial trials of a vitamin D supplement vs. placebo, a combination of vitamin C + vitamin B complex + zinc vs. placebo, and an Omega-3 supplement (comprised of DHA/EPA fatty acids) vs. placebo, to investigate the effects on mortality risk, severe outcomes and …

  • 10 Apr, 2021
  • 1 location
Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by Ivabradine

MODIfY is a prospective, single center, open label, randomized, controlled two arms, Phase II-trial to evaluate the ability of ivabradine to reduce an elevated heart rate in Multiple Organ Dysfunction Syndrome (MODS) patients. The primary end point is the proportion of patients with a reduction of heart rate by at …

organ dysfunction syndrome
  • 08 Nov, 2020
  • 1 location
6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome

Background: Systemic corticosteroids are considered in patients with an adverse clinical course suffering from conditions like the acute respiratory distress syndrome (ARDS) and septic shock. Treated patients not only show improved respiratory function, but also hemodynamic status and overall multiple organ dysfunction score. Objective: To evaluate the safety and effectiveness …

organ dysfunction syndrome
  • 07 Nov, 2020
  • 4 locations
Acute Pancreatitis Targets (APT) Study

The severity of acute pancreatitis varies considerably from minor symptoms to multi-organ failure. The pathophysiological mechanisms associated with these individual differences in severity are

  • 04 Feb, 2021
  • 1 location
Prehabilitation & Rehabilitation in Oncogeriatrics: Adaptation to Deconditioning Risk and Accompaniment of Patients' With Cancer

functional deconditioning or organ failure. Surgery or complex medico-surgical procedures - that associate chemotherapy and/or radiotherapy and surgery, can be considered as one proof-of principle of

  • 24 Feb, 2021
  • 12 locations
Medical Herbs Inhibit Inflammation Directing T Cells to Kill the COVID-19 Virus (COVID)

causes an immune-storm (cytokine-storm) that can directly damage the organ(s), leading to death. The virus is an antigen - a trigger - but it is not the actual reason that causes organ failure and death

  • 19 Mar, 2021
  • 1 location