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Found 26 clinical trials
6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome

effectiveness of 6-methyl-prednisolone on the clinical course of multiple organ dysfunction syndrome (MODS). Design: Multi-center, double-blind, randomized, placebo-controlled. Intervention

corticosteroids
prednisolone
shock
organ dysfunction syndrome
  • 8 views
  • 07 Nov, 2020
  • 4 locations
Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by Ivabradine

Organ Dysfunction Syndrome (MODS) patients. The primary end point is the proportion of patients with a reduction of heart rate by at least 10 beats per minute (bpm) within 4 days. This trial

beta-blockers
organ dysfunction syndrome
  • 2 views
  • 08 Nov, 2020
  • 1 location
Facilitating Communication Study

This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their families to secure care in line with patients' goals of care over an illness trajectory, …

acute illness
cognitive impairment
stroke
respiratory distress
cancer
  • 269 views
  • 26 Jan, 2021
  • 5 locations
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis

The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether balanced fluid resuscitation can reduce progression of kidney injury.

lactated ringer's solution
crystalloid
septic shock
plasma-lyte
sepsis
  • 0 views
  • 01 Aug, 2021
  • 1 location
Closed or Open Abdomen for the Management of Abdominal Sepsis

This is a prospective randomized clinical study. The study will comprise the randomized decision to either A) primarily close the fascia after laparotomy for intra-abdominal infection (CLOSED); or B) leave the fascia open after laparotomy and apply a temporary abdominal closure (TAC) device (OPEN) with a vacuum drain. Although debatable, …

laparotomy
clinical decision making
sepsis
  • 0 views
  • 26 Jan, 2021
  • 1 location
Eculizumab to Treat Thrombotic Microangiopathy/Atypical Hemolytic Uremic Syndrome -Associated Multiple Organ Dysfunction Syndrome in Hematopoietic Stem Cell Transplant Recipients

Hematopoietic stem cell transplantation (HCT)-associated thrombotic microangiopathy (TMA) is an understudied complication of HCT that significantly affects transplant related morbidity and mortality. The investigators hypothesize that early intervention with complement blocker eculizumab will double survival in HCT recipients with high risk TMA, as compared to historical untreated controls. An optimal …

renal replacement
organ dysfunction syndrome
stem cell transplantation
eculizumab
replacement therapy
  • 3 views
  • 24 Jun, 2021
  • 3 locations
Use of Extracorporeal Treatment With the Cytosorb-Adsorber for the Reduction of SIRS in Heart Surgery Patients

Heart-surgery with the use of a heart-lung-machine can trigger the development of a full-blown SIRS (Systemic Inflammatory Response Syndrom) with multi organ failure and severe sepsis in the course of disease. For the treatment of full-blown SIRS extracorporeal treatment like the Cytosorb-Adsorber are in clinical testing. The Cytosorb-Adsorber is a …

severe sepsis
vasopressor
systemic inflammatory response syndrome
cytokines
sepsis
  • 0 views
  • 24 Jan, 2021
  • 1 location
TPE in Septic Patients and Influence on Organ Failure

Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study focusing on the organ functions of the patients.

shock
  • 0 views
  • 24 Jan, 2021
  • 1 location
Pediatric Immune Response to Multi-Organ Dysfunction

Multiple organ dysfunction (MOD) is defined by the association of at least two failures of vital organs, with various etiologies (septic shock, polytrauma, acute respiratory distress syndrome, etc.). Associated mortality remains high in children (between 20 and 50%). In septic shock, one of the main causes of MOD, induced immunosuppression …

  • 0 views
  • 14 Jun, 2021
  • 2 locations
Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients

: Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients. As the

trauma injury
  • 16 views
  • 02 Jun, 2021
  • 1 location