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Found 85 clinical trials
Pembrolizumab With Chemotherapy for Poorly Chemo-responsive Thyroid and Salivary Gland Tumors (iPRIME)

Phase II, 2-cohort, single arm trial treated with the combination of the following two agents Pembrolizumab (MK3475) 200mg, every three weeks, iv Docetaxel 75mg/m2, every three weeks, iv

gilbert's syndrome
carcinoma
anticoagulants
docetaxel
pembrolizumab
  • 119 views
  • 28 Apr, 2022
  • 1 location
Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy

This study aims to propose an alternative and auxiliary methodology for the prevention and treatment of Oral Mucositis (OM) in patients undergoing radiotherapy or radio and chemotherapy for head and neck neoplasms through the use of copaiba-based mouthwash, since the treatment that currently has proven efficacy for the prevention of …

head and neck neoplasms
neck tumor
oral cancer
carcinoma
intensity-modulated radiation therapy
  • 0 views
  • 23 Apr, 2022
  • 1 location
Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis

As mentioned above, several prior studies have shown the positive effects of oral use of aloe vera juice in managing chemotherapy and radiation-induced oral mucositis and esophagitis. This study aims to add to the existing body of research around aloe vera juice and its effects on oral mucositis and esophagitis. …

mucositis
  • 0 views
  • 26 May, 2022
  • 1 location
Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers

This phase I/II trial studies the side effects and how well nivolumab and ipilimumab works when given together with stereotactic body radiation therapy (SBRT) in treating patients with salivary gland cancers. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and …

metastasis
ipilimumab
measurable disease
neutrophil count
carcinoma
  • 0 views
  • 10 May, 2022
  • 1 location
Customized 3D Printed Oral Stents During Head and Neck Radiotherapy

This clinical trial studies the effect of customized 3 dimensional (3D) printed oral tents on patients with head and neck cancer who are receiving radiotherapy. Oral stents are made from the impression of patients' mouth and cover patients' teeth and gums during radiation therapy. A customized, 3D-printed oral stent may …

  • 0 views
  • 08 Nov, 2021
  • 4 locations
Cell-free Tumor DNA in Head and Neck Cancer Patients

This study investigates if head and neck squamous cell carcinoma can be tracked with cell-free tumor DNA, RNA or HPV-DNA, in blood samples from patients referred with suspicion of cancer, and if it can be used in detecting recurrence in patients already diagnosed and treated for head and neck squamous …

neck cancer
squamous cell carcinoma of head and neck
cancer
squamous cell carcinoma
carcinoma
  • 15 views
  • 06 Feb, 2022
  • 1 location
Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

This study will examine the combination of pembrolizumab and tadalafil for safety and efficacy in advanced head and neck cancer.

neck cancer
metastatic squamous cell carcinoma
metastatic head and neck cancer
squamous cell carcinoma
advanced head and neck carcinoma
  • 12 views
  • 05 Mar, 2022
  • 1 location
Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer

The purpose of this study is to compare any good or bad effects of using pembrolizumab (an experimental drug) and radiation therapy (RT), compared to using cisplatin chemotherapy and radiation therapy (RT) in the treatment of patients with head and neck squamous cell carcinoma (HNSCC).

neck cancer
squamous cell carcinoma of the head and neck
squamous cell carcinoma
carcinoma
cavity
  • 1 views
  • 04 Mar, 2022
  • 7 locations
STEREO-POSTOP 01 (PostOperative Hypofractionated Stereotactic Body Radiotherapy ) - GORTEC 2017-03 (STEREOPOSTOP)

treatment of early stage oropharyngeal and oral cavity cancer with high risk margins.

neck dissection
squamous cell carcinoma
carcinoma
mouth cancer
dental caries
  • 4 views
  • 27 Feb, 2022
  • 14 locations
9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma

This trial is investigating an intravenous (IV) medication called 9-ING-41 in combination with chemotherapy (carboplatin) for the treatment of advanced salivary gland cancers. The names of the study drug(s) involved in this study are: 9-ING-41 (a GSK-3 inhibitor) Carboplatin chemotherapy

biological factors
carboplatin
cancer
neutrophil count
carcinoma
  • 0 views
  • 27 Oct, 2021
  • 2 locations