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Found 83 clinical trials
Radiotherapy of Head and Neck Cancer Using an Intraoral Stent

Radiotherapy of oral cavity cancer and sinonasal cancer is associated with acute and late morbidity. Use of an intraoral stent will provide a larger distance between the tongue and palate and

carcinoma of oral cavity
neck cancer
head and neck cancer
caries
  • 0 views
  • 15 Jun, 2021
  • 1 location
Submandibular Gland Preservation in Neck Dissection

Trial design: a randomized controlled trial. Eligibility criteria for participants: patients with primary early stage oral squamous cell carcinoma. Exclusion criteria: cancer of the floor of the mouth. Interventions: submandibular gland is preserved during neck dissection for patients of the experimental group; submandibular gland is removed during neck dissection for …

squamous cell carcinoma
carcinoma
neck dissection
  • 0 views
  • 06 Oct, 2021
  • 1 location
Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors

This phase IV trial studies how well serial magnetic resonance imaging (MRI) after radiation therapy works in predicting radiation-induced changes in the normal tissue of patients with oral cavity or skull base tumors. Performing MRIs after radiation therapy for patients with oral cavity or skull base tumors may help to …

caries
  • 0 views
  • 09 Jan, 2022
  • 1 location
Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue

prospective clinical trial. Positive outcomes from this study have the potential to dramatically alter the most common morbidity of oral cancer therapy, namely speech and swallowing function in a population

oral cancer
new diagnosis
cancer treatment
  • 21 views
  • 11 Jul, 2021
  • 1 location
Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers

This phase I/II trial studies the side effects and how well nivolumab and ipilimumab works when given together with stereotactic body radiation therapy (SBRT) in treating patients with salivary gland cancers. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and …

nivolumab
platelet count
carcinoma
neutrophil count
ipilimumab
  • 0 views
  • 29 Jul, 2021
  • 1 location
APG-115 in Salivary Gland Cancer Trial

This is a phase I/II trial to evaluate the efficacy of APG-115 +/- Carboplatin for the treatment p53 wild-type malignant salivary gland cancer. Part 1 consisted of 2 arms, arm A (APG-115 monotherapy) and arm B (APG-115 + Carboplatin) and was terminated early. Part 2 is a single arm study …

  • 0 views
  • 26 Dec, 2021
  • 3 locations
PSMA-PET Imaging Before and After ADT in Advanced SDC Patients

Explorative study, which evaluates the effect of androgen deprivation therapy (ADT) on the PSMA ligand uptake on 68Ga-PSMA-PET/CT in salivary duct carcinoma patients.

  • 1 views
  • 16 Apr, 2021
  • 1 location
Correlation of FAZA PET Hypoxia Imaging To 3D Histology in Oral Tongue Cancer

This is a pilot study in the form of a prospective Phase II, single centre, single arm hypoxia study of oral tongue cancer with FAZA-PET imaging and pimonidazole targeted IHC of surgical specimens.

hypoxia
international normalized ratio
fluoroazomycin arabinoside
platelet count
squamous cell carcinoma
  • 39 views
  • 28 Oct, 2021
  • 1 location
Post-op T-DM1 in HER-2+ Salivary Gland Carcinomas

This research is being done to see how safe and effective the use of the study drug Ado-trastuzumab (T) emtansine (DM1), T-DM1, and standard of care chemoradiation are when used together in treating HER2-positive salivary gland cancer. It will also examine the effectiveness of study drug Ado-trastuzumab (T) emtansine (DM1) …

  • 1 views
  • 09 Jan, 2022
  • 2 locations
Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers

The purpose of this study is to see if the study drugs, lenvatinib and pembrolizumab, are effective in treating advanced Adenoid Cystic Carcinoma (ACC) or other salivary gland cancers that have come back and/or spread to other parts of the body. Researchers are also doing this study to test the …

measurable disease
ct scan
cancer
pembrolizumab
anticoagulants
  • 0 views
  • 03 Jan, 2022
  • 8 locations