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Found 87 clinical trials
Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue Cancers

A prospective multicenter randomized non-inferiority clinical trial, to evaluate the efficacy and safety of 1.0 cm-safety margin surgery, compared with 1.5 cm safety margin surgery for cT1-2N0 oral tongue cancer Summary A current standard primary treatment for oral tongue cancer is a curative surgical resection with/without adjuvant radiation treatments (or …

  • 0 views
  • 12 May, 2022
  • 1 location
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).

solid tumor
solid tumour
solid neoplasm
thyroid carcinoma
carcinoma
  • 15 views
  • 23 Jul, 2022
  • 24 locations
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) (STARTRK-2)

This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.

cancer chemotherapy
crizotinib
solid tumor
solid tumour
targeted therapy
  • 16 views
  • 12 Jul, 2022
  • 9 locations
Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"

The main goal of this phase of the study is to determine if objectively assessed Physical Activity (PA) levels in advanced-cancer patients are associated with health care provider (HCP)-assessed ECOG performance status and overall survival. The purpose is to advance the evidence-base for incorporating objective assessment of Physical Activity (PA) …

metastasis
radiation oncology
cavity
primary cancer
advanced cancer
  • 43 views
  • 03 Jun, 2022
  • 1 location
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

vasectomy
pecoma
cancer other
amylase
gastrointestinal stromal tumor
  • 6634 views
  • 10 Aug, 2022
  • 752 locations
Adjuvant Radiotherapy in Early Stage Oral Cancers (AREST)

This study will assess the benefit of postoperative adjuvant radiotherapy in patients with an early oral squamous cell carcinoma (OSCC) having tumor thickness more than or equal to 5mm. The study population will consist of patients who have been treated by surgery for early stage oral tongue cancers. Patients with …

cavity
squamous cell carcinoma of the oral cavity
mouth cancer
immunomodulator
dental caries
  • 22 views
  • 13 May, 2022
  • 5 locations
Topical Aldara (Imiquimod) for Oral Cancer

The purpose of this research study is to find out what effects, good and/or bad, topical application of the drug Aldara will have on patients and on their oral cancer. Aldara is a drug that

squamous cell carcinoma
carcinoma
tumor cells
oral cancer
  • 0 views
  • 25 May, 2022
  • 1 location
Using MASL to Combat Oral Cancer

This project will evaluate the expression of a receptor called podoplanin (PDPN) in cells from oral cancers and precancerous lesions. We will also determine how sensitive oral cancer cells are

oral cancer
cancer
  • 2 views
  • 09 May, 2022
  • 2 locations
Screening for Cancers in the Oral CAvity

In the Somme region of France, cancer registry data showed an increasing incidence of oral cancer. The Incidence Rates in Somme as compared to the national rates for Lip, Oral Cavity and Pharynx

caries
carcinoma of oral cavity
  • 25 views
  • 29 Aug, 2021
  • 1 location
The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor

Cervical nodal metastasis is the most certain prognostic factor in oral cancer. Appropriate management of the neck is therefore of paramount importance in the treatment of oral cancer. However

metastasis
carcinoma
oral cancer
neck dissection
  • 16 views
  • 24 Feb, 2022