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Found 88 clinical trials
Radiotherapy of Head and Neck Cancer Using an Intraoral Stent

Radiotherapy of oral cavity cancer and sinonasal cancer is associated with acute and late morbidity. Use of an intraoral stent will provide a larger distance between the tongue and palate and

neck cancer
carcinoma of oral cavity
head and neck cancer
caries
  • 0 views
  • 03 Mar, 2022
  • 1 location
The Oral Microbiome in OSCC

understanding of how particular bacterial species, or consortia of species, can result in an individual having an increased risk of the most common type of oral cancer -- oral squamous cell carcinoma. This

squamous cell carcinoma
carcinoma
oral cancer
  • 0 views
  • 30 May, 2022
Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors

This phase IV trial studies how well serial magnetic resonance imaging (MRI) after radiation therapy works in predicting radiation-induced changes in the normal tissue of patients with oral cavity or skull base tumors. Performing MRIs after radiation therapy for patients with oral cavity or skull base tumors may help to …

caries
  • 0 views
  • 26 Feb, 2022
  • 1 location
Submandibular Gland Preservation in Neck Dissection

Trial design: a randomized controlled trial. Eligibility criteria for participants: patients with primary early stage oral squamous cell carcinoma. Exclusion criteria: cancer of the floor of the mouth. Interventions: submandibular gland is preserved during neck dissection for patients of the experimental group; submandibular gland is removed during neck dissection for …

squamous cell carcinoma
neck dissection
carcinoma
  • 0 views
  • 01 Mar, 2022
  • 1 location
Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue (PGSRT)

prospective clinical trial. Positive outcomes from this study have the potential to dramatically alter the most common morbidity of oral cancer therapy, namely speech and swallowing function in a population

new diagnosis
oral cancer
cancer treatment
  • 21 views
  • 25 Mar, 2022
  • 1 location
A Study of Drug Therapies for Salivary Gland Cancers Based on Testing of Genes

This is a study of select drug therapies in patients with salivary gland cancer. The study has two phases: a molecular profiling phase (phase 1) and a treatment phase (phase 2). Based on the Molecular profiling results in phase the participants will receive matched treatment if a specific aberration is …

  • 13 views
  • 15 Mar, 2022
  • 1 location
Correlation of FAZA PET Hypoxia Imaging To 3D Histology in Oral Tongue Cancer (FAITH)

This is a pilot study in the form of a prospective Phase II, single centre, single arm hypoxia study of oral tongue cancer with FAZA-PET imaging and pimonidazole targeted IHC of surgical specimens.

neutrophil count
international normalized ratio
fluoroazomycin arabinoside
hypoxia
platelet count
  • 39 views
  • 02 Mar, 2022
  • 1 location
APG-115 in Salivary Gland Cancer Trial

This is a phase I/II trial to evaluate the efficacy of APG-115 +/- Carboplatin for the treatment p53 wild-type malignant salivary gland cancer. Part 1 consisted of 2 arms, arm A (APG-115 monotherapy) and arm B (APG-115 + Carboplatin) and was terminated early. Part 2 is a single arm study …

  • 0 views
  • 21 Mar, 2022
  • 2 locations
PSMA-PET Imaging Before and After ADT in Advanced SDC Patients (ADT-SCAN)

Explorative study, which evaluates the effect of androgen deprivation therapy (ADT) on the PSMA ligand uptake on 68Ga-PSMA-PET/CT in salivary duct carcinoma patients.

  • 1 views
  • 25 Feb, 2022
  • 1 location
Post-op T-DM1 in HER-2+ Salivary Gland Carcinomas

This research is being done to see how safe and effective the use of the study drug Ado-trastuzumab (T) emtansine (DM1), T-DM1, and standard of care chemoradiation are when used together in treating HER2-positive salivary gland cancer. It will also examine the effectiveness of study drug Ado-trastuzumab (T) emtansine (DM1) …

  • 1 views
  • 09 Jan, 2022
  • 2 locations