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Found 89 clinical trials
Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue Cancers

A prospective multicenter randomized non-inferiority clinical trial, to evaluate the efficacy and safety of 1.0 cm-safety margin surgery, compared with 1.5 cm safety margin surgery for cT1-2N0 oral tongue cancer Summary A current standard primary treatment for oral tongue cancer is a curative surgical resection with/without adjuvant radiation treatments (or …

  • 0 views
  • 12 May, 2022
  • 1 location
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).

endometrial carcinoma
carcinoma
solid tumour
thyroid carcinoma
adenocarcinoma
  • 14 views
  • 15 Jun, 2022
  • 25 locations
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) (STARTRK-2)

This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.

proto-oncogene tyrosine-protein kinase ros
solid tumour
leptomeningeal carcinomatosis
targeted therapy
small molecule
  • 16 views
  • 17 Jun, 2022
  • 9 locations
Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"

The main goal of this phase of the study is to determine if objectively assessed Physical Activity (PA) levels in advanced-cancer patients are associated with health care provider (HCP)-assessed ECOG performance status and overall survival. The purpose is to advance the evidence-base for incorporating objective assessment of Physical Activity (PA) …

oropharyngeal
cancer diagnosis
cavity
non-melanoma skin cancer
adenocarcinoma
  • 43 views
  • 03 Jun, 2022
  • 1 location
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

extrahepatic cholangiocarcinoma
human immunodeficiency virus
carcinoma
bronchoalveolar carcinoma
teratoma
  • 6632 views
  • 29 Jun, 2022
  • 759 locations
Adjuvant Radiotherapy in Early Stage Oral Cancers (AREST)

This study will assess the benefit of postoperative adjuvant radiotherapy in patients with an early oral squamous cell carcinoma (OSCC) having tumor thickness more than or equal to 5mm. The study population will consist of patients who have been treated by surgery for early stage oral tongue cancers. Patients with …

mouth cancer
carcinoma
caries
squamous cell carcinoma of the oral cavity
intensity-modulated radiation therapy
  • 22 views
  • 13 May, 2022
  • 5 locations
Topical Aldara (Imiquimod) for Oral Cancer

The purpose of this research study is to find out what effects, good and/or bad, topical application of the drug Aldara will have on patients and on their oral cancer. Aldara is a drug that

carcinoma
tumor cells
squamous cell carcinoma
oral cancer
  • 0 views
  • 25 May, 2022
  • 1 location
Using MASL to Combat Oral Cancer

This project will evaluate the expression of a receptor called podoplanin (PDPN) in cells from oral cancers and precancerous lesions. We will also determine how sensitive oral cancer cells are

cancer
oral cancer
  • 2 views
  • 09 May, 2022
  • 2 locations
Screening for Cancers in the Oral CAvity

In the Somme region of France, cancer registry data showed an increasing incidence of oral cancer. The Incidence Rates in Somme as compared to the national rates for Lip, Oral Cavity and Pharynx

carcinoma of oral cavity
caries
  • 25 views
  • 29 Aug, 2021
  • 1 location
The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor

Cervical nodal metastasis is the most certain prognostic factor in oral cancer. Appropriate management of the neck is therefore of paramount importance in the treatment of oral cancer. However

oral cancer
neck dissection
carcinoma
metastasis
  • 16 views
  • 24 Feb, 2022