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Found 10 clinical trials
Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection (TAPER-V)

The first line therapy for an initial episode of CDI (Clostridium difficile infection) is 10-14 days of oral vancomycin which is now recommended over metronidazole in the 2018 guidelines from

  • 0 views
  • 19 Apr, 2022
  • 3 locations
Evaluation of CRS3123 vs. Oral Vancomycin in Adult Patients With Clostridioides Difficile Infection

The purpose of this research is to evaluate the primary objectives of safety and efficacy (rate of clinical cure) of 2 dosages of CRS3123 (200 mg and 400 mg) administered orally (po) twice daily (bid) and vancomycin administered 125 mg PO 4 times daily (qid) in adults > or equal …

  • 0 views
  • 11 Jul, 2022
  • 25 locations
Oral Vancomycin vs Placebo in the Prevention of Recurrence of Clostridioides Difficile's Infection (PREVAN)

A phase III randomized clinical trial in proportion 2:1 in favor of oral vancomycin (experimental treatment), multicentric, national, double-blinded, controlled with placebo. The main objective

  • 0 views
  • 09 Aug, 2022
  • 1 location
ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infection

Segments 2A and 2B of this trial evaluate the safety, efficacy, pharmacokinetics, fecal concentrations, and fecal microbiome effects of ACX-362E [ibezapolstat] in patients with C. difficile infection (CDI).

stool test
aspart
diarrhea
  • 0 views
  • 02 Jul, 2022
  • 15 locations
Optimal Treatment for Recurrent Clostridium Difficile (OpTION)

The purpose of this study is to determine whether fidaxomicin and vancomycin followed by taper and pulse vancomycin treatment are superior to standard vancomycin treatment for the treatment of recurrent Clostridium difficile infection.

  • 87 views
  • 24 Mar, 2022
  • 23 locations
Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection

This study evaluates the efficacy of prophylaxis with oral vancomycin for preventing recurrent Clostridium difficile Infection (CDI) in patients who have experienced at least one CDI episode in

oral vancomycin
vancomycin
clostridium difficile
antibiotic therapy
antibiotics
  • 12 views
  • 28 Feb, 2022
  • 4 locations
MTT for Children With ASD Who Have Gastrointestinal Disorders

diarrhea). MTT involves a combination of 10 days of oral vancomycin (an antibiotic to kill pathogenic bacteria), followed by a bowel cleanse, followed by 12 weeks of Fecal Microbiota (FM).

oral vancomycin
vancomycin
autism
gastrointestinal disorder
antibiotics
  • 19 views
  • 20 Feb, 2022
  • 1 location
Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT) (ACT)

This is a randomized, double-blind, placebo-controlled trial to determine the optimal dose and safety of oral alanyl-glutamine between 4, 24, and 44 g doses administered for 10 days with standard therapy among first time incident cases of uncomplicated C. difficile infection (CDI) in hospitalized persons aged 65 or older. Our …

  • 0 views
  • 14 Jun, 2022
  • 1 location
A Screening and Recruitment Study in Adults Expressing Interest in the Emory Microbiota Enrichment Program (MEP)

The goal of this study is to rapidly identify subjects who are eligible for the Microbiota Enrichment Program (MEP) at Emory in Atlanta, Georgia. This general screening protocol will be used to screen potential subjects for the Emory MEP and will be conducted at the Emory Clinic, the Hope Clinic …

microbiota
  • 0 views
  • 20 Apr, 2022
  • 3 locations
A Systems Biology Approach for Identification of Host and Microbial Mechanisms and Druggable Targets for the Treatment of PSC-IBD (PSC-Vanc)

metabolism, bile acid signalling, and a central role of enteric dysbiosis. In parallel, pilot data from other groups have shown that treatment with oral vancomycin (a non-absorbable, gut-specific antibiotic

cancer
colitis
enteropathy
endoscopy
antibiotics
  • 0 views
  • 16 Jun, 2022
  • 1 location