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Found 92 clinical trials
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Oral Cancer Adjuvant Therapy (OCAT) Trial

To demonstrate whether addition of Concurrent chemotherapy to post-operative adjuvant radiotherapy OR shortening of duration of post-operative radiotherapy, by administering 6 fractions / week instead of 5 fractions / week improves local-regional control and / or overall survival in high risk, locally advanced, resectable, squamous cell carcinoma of oral cavity.

adjuvant therapy
squamous cell carcinoma of the oral cavity
carcinoma of oral cavity
chemoradiotherapy
carcinoma
  • 60 views
  • 07 Nov, 2020
  • 1 location
None
Dissecting the Heterogeneity of Oral Cancer Pain

Oral squamous cell carcinoma (SCC) produces a higher prevalence and more severe pain than all other cancers. Orofacial pain is one of the most common initial symptoms of oral cancer and often

  • 0 views
  • 04 Sep, 2021
  • 1 location
None
Pharmacokinetic (PK) Analysis of Antitumor B in Patients With Oral Cancer

A Window of Opportunity Clinical Trial. This study design permits examination of effects of an oral agent on cancer patients during the "window" between diagnosis of their cancer and their definitive cancer surgery. Similar to a phase 0 study, the trial design permits examination of the biologic effects of an …

  • 6 views
  • 26 Sep, 2021
  • 1 location
None
Surgery and Radiation Therapy With or Without Interleukin-2 in Treating Patients With Cancer of the Mouth or Oropharynx

surgery and radiation therapy alone to see how well they work compared to surgery, radiation therapy, and interleukin-2 in treating patients with cancer of the mouth or oropharynx.

tumor cells
oral cancer
interleukin-2
x-rays
immunomodulator
  • 18 views
  • 07 Nov, 2020
  • 1 location
None
  • 4 views
  • 21 Jan, 2021
  • 2 locations
None
Safety and Potential Efficacy of MS-20 In Combination With Pembrolizumab for the Treatment of NSCLC

MS-20 was approved as the first oral cancer adjuvant new drug indicated for ameliorating fatigue and appetite loss associated with cancer chemotherapy via reshaping human gut ecosystem and

  • 0 views
  • 16 Oct, 2021
  • 4 locations
None
Free Soft Tissue Graft in Treatment of Oral Lichen Planus

influence the risk for oral cancer. The purpose of the study is to determine the efficacy of free soft tissue graft in the treatment of precancerous and symptomatic lesions of OLP. Removal of

epithelial cells
antioxidant
precancerous lesions
corticosteroids
cancer
  • 0 views
  • 07 Nov, 2020
  • 1 location
None
Immune Checkpoint Inhibitor In High Risk Oral Premalignant Lesions

size or in grade of dysplasia) may not be enough to assess the potential benefit of an intervention. Modulation of molecular markers may be more precise indicator of oral cancer risk in patients with

  • 0 views
  • 27 Jan, 2021
  • 5 locations
None
Oral Potentially Malignant Disorders: Comparison Between Surgical Treatment and Wait and See Approach

This research protocol is comparing the effectiveness of surgical excision to the "wait and see" approach for the management of oral leukoplakia and erythroleukoplakia in prevention of oral squamous cell carcinoma onset.

  • 0 views
  • 08 May, 2021
  • 1 location
None
Concomitant Immune Check Point Inhibitor With Radiochemotherapy in Head And Neck Cancer

Background: Locally advanced head and neck cancer (HNC) is a challenge as, in spite of initial good control with chemoradiation, the majority of patients fails systemically. In the last 2 years, immune check points inhibitors (mainly Programmed Death (PD)-1 inhibitors) were approved for metastatic/recurrent HNC. The favorable toxicity profile and …

  • 25 views
  • 26 Apr, 2021
  • 1 location