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Found 743 clinical trials
Pain Avoidance Behavior and Its Relation to Risk for Opioid Use in Chronic Pain Patients

This study is designed to find behavioral and neurophysiological correlates of pain avoidance behavior among chronic pain patients, controlling for risk for opioid use disorder. Further, traits and risk factors that contribute to pain avoidance behavior will be investigated. The knowledge gained will broaden the current understanding of mechanisms involved …

chronic pain
  • 23 Mar, 2022
  • 1 location
Covid-related Opioid Treatment Policy Evaluation

Our nation is facing the COVID-19 pandemic during an ongoing opioid epidemic. Effective treatment for patients with opioid use problems involves a treatment method called Medication-Assisted Treatment, or MAT. In MAT, patients receive a medication that reduces cravings and withdrawal symptoms and can prevent overdose. Patients also receive counseling. Because …

Accepts healthy volunteers
  • 06 Oct, 2021
  • 1 location
Does Medical Cannabis Reduce Opioid Use in Adults With Pain (ReLeaf-E)

The study will examine how medical cannabis use affects opioid analgesic use. This landmark study will be among the first to examine the effect of medical cannabis with different THC/CBD content on opioid use as well as adverse events.

medical marijuana
cannabis use
substance use
  • 25 Mar, 2022
  • 1 location
Patient Reported Outcomes Following Targeted Muscle Reinnervation

The purpose of this study is to characterize the functional status and quality of life of patients undergoing Targeted Muscle Reinnervation (TMR) at time of major limb amputation (primary) or subsequent to major limb amputation (secondary). Participants can expect to be on study for about a year and will complete …

limb amputation
  • 14 Nov, 2021
  • 1 location
Medical Cannabis Against Chronic Musculoskeletal Pain: a Mixed Methods Study.

Despite many pharmaceutical options, there are no optimal treatments for Chronic musculoskeletal pain (CMP). Although many Canadians use medical cannabis (MC; legally authorized) to relieve their pain, there are no firm conclusions on the efficacy and safety of MC against CMP. In order to increase knowledge on this topic, it …

  • 21 Mar, 2022
  • 1 location
MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study

This is a multi-center prospective comparative cohort study examining the safety, efficacy, pharmacokinetics, and pharmacogenomics of naltrexone for pregnant women with opioid use disorder. Pregnancy, delivery, and maternal and infant outcomes to 12 months post-delivery will be examined and compared with a cohort treated with buprenorphine/naloxone.

opioid use
opioid use disorder
  • 18 Aug, 2021
  • 2 locations
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis. The investigators will image brain cannabinoid receptors using Positron Emission Tomography (PET) imaging and the radioligand …

psychiatric disorder
cannabis use
opioid use disorder
prodromal syndromes
pet scan
  • 14 Mar, 2022
  • 1 location
The Effect of Ergonomic Sleep Mask Usage on Patients' Sleep Quality and Comfort

In intensive care units, the sleep quality of patients decreases considerably due to reasons such as alarm sounds of some special devices, the number of healthcare professionals working in comparison to other clinics, their circulation is high, and the lights are constantly on.Studies conducted in intensive care units to facilitate …

  • 13 Apr, 2022
Implementation and Evaluation of a Stepped-Care Mental Health Treatment Program for Patients With Chronic Pain

Chronic pain affects nearly 20% of Canadians, and sixty percent or more of individuals with chronic pain are also struggling with mental health or substance use disorders (referred to as complex chronic pain, or CCP, patients). This is a major concern in the best of times and has become an …

depressive symptoms
behavior therapy
acceptance and commitment therapy
  • 10 Oct, 2021
  • 1 location
Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

Background People with addictions often find it hard to choose the long-term benefits of abstinence over the short-term effects of using drugs. Researchers think this is partly due to parts of the brain involved in certain types of learning and decision-making. Researchers want to test these basic functions using a …

urine screening
toxicology screen
  • 29 Jun, 2022
  • 1 location