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Found 11 clinical trials
Featured trial
A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Investigational Product in Patients With Non-Cancer-Related Pain and Opioid-Induced Constipation (OIC)

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Investigational Product in Patients With Non-Cancer-Related Pain and Opioid-Induced Constipation (OIC)

  • 714 views
  • 25 Mar, 2021
  • 1 location
Methylnaltrexone vs Naloxegol in the Treatment of Opioid-Induced Constipation

The purpose of this study is to compare the efficacy of subcutaneous versus oral mu-opioid receptor antagonist therapy in opioid induced constipation that is refractory to other bowel regimens

  • 30 views
  • 10 Apr, 2022
  • 1 location
Effects of Peripherally Acting µ-opioid Receptor Antagonists on Acute Pancreatitis

This study will investigate the effect of peripheral acting opioid antagonist (PAMORA) on the disease course of patients with acute inflammation of the pancreas (acute pancreatitis). The study will be conducted by treating hospitalized patients with acute pancreatitis with a PAMORA (methylnaltrexone).

  • 0 views
  • 13 Dec, 2021
  • 4 locations
Safety and Preliminary Efficacy of BGP345A in Constipation Due to Opioid-based Medications (OIC1)

The purpose of this study is to assess safety and preliminary efficacy of BGP345A in patients with constipation due to the use of opioid-based medications for the management of chronic non cancer pain.

  • 0 views
  • 26 Mar, 2022
  • 3 locations
Naloxegol and Opioid-induced Constipation

This is a double-blind, randomized, placebo-controlled trial to examine the effectiveness of adding one 25mg dose of naloxegol to the cardiac surgery pre-operative regimen.

opioid-induced constipation
naloxegol
opioid
  • 20 views
  • 10 May, 2022
  • 1 location
Regional Blocks for Lateral Condyle Fractures

2 will undergo the Orthopaedic Institute of Children's (OIC) standard preoperative protocol. Post-operative pain management will be the same for both groups per standard protocol. Pain level will be

open reduction
pain medication
oxycodone
pain relieving
opioid
  • 14 views
  • 03 Mar, 2022
  • 1 location
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections

The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patient outcomes and reduce the development of antibiotic resistance. The project aims are: (i) To improve the current diagnostic approaches and …

  • 0 views
  • 29 Aug, 2021
  • 1 location
European Study of Opioid Induced Constipation

patients. However, it is well recognised that opioid analgesics are a common cause of constipation in this group. The prevalence of opioid-induced constipation (OIC) is stated to be 40-70%, although a

  • 0 views
  • 17 Dec, 2021
  • 1 location
Risk of Major Adverse Cardiovascular Events for Naldemedine and Other Medications for Opioid Induced Constipation in Adults With Chronic Non-Cancer Pain

comparator opioid induced constipation (OIC) medications.

cancer pain
cancer
analgesics
naloxegol
lubiprostone
  • 6 views
  • 10 Mar, 2022
  • 1 location
Naloxegol Health Outcome Post Authorisation Safety Study

This post-authorization observational safety study (PASS) monitors clinically important identified and potential risks within a cohort of patients treated with naloxegol, including the occurrence of bowel perforation, acute myocardial infarction (MI), stroke, cardiovascular (CV)-specific mortality, all-cause mortality, hypertension, opioid withdrawal, abdominal pain, diarrhea, syncope, and change in pain severity. This …

abdominal pain
bowel perforation
naloxegol
hypertension
laxative
  • 0 views
  • 26 Jan, 2022
  • 3 locations