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Found 104 clinical trials
Increasing Access to Hepatitis C Treatment in Opioid Endemic Rural Areas: The Kentucky Viral Hepatitis Treatment (KeY Treat) Study (KeY Treat)

The overarching goal of the Kentucky Viral Hepatitis Treatment Project (KeY Treat) is to increase hepatitis C virus (HCV) treatment access and delivery in a rural Appalachian community, which is in the midst of the opioid/hepatitis C (HCV) syndemic. KeY Treat is a clinical research study seeking to determine whether …

sofosbuvir/velpatasvir
sofosbuvir
velpatasvir
antiviral drugs
epclusa
  • 13 views
  • 12 Oct, 2022
  • 1 location
Encouraging Abstinence Behavior in a Drug Epidemic

substance abuse. However, the use of incentives by treatment facilities remains extremely low. Furthermore, it is not well understood how to design optimal incentives to treat opioid abuse. This project

  • 136 views
  • 04 Oct, 2022
  • 1 location
A Randomized Clinical Trial to Evaluate Non-Pharmacologic and Pharmacologic Approaches for Reducing Pain and Opioid Use Among Patients Treated With Maintenance Hemodialysis (HOPE)

HOPE is a randomized clinical trial that will evaluate approaches to reducing pain and opioid use among patients with chronic pain who are receiving maintenance hemodialysis for end-stage renal disease. The hypothesis is that pain coping skills training will be effective at reducing pain and opioid use, and that buprenorphine …

chronic pain
motivational interviewing
opioid use
opioid agonist
buprenorphine
  • 31 views
  • 21 Oct, 2022
  • 15 locations
I-COPE Study: Opioid Use and Pain Management in Older Adults

what it was previously. This surge is accompanied with a drastic increase of older adults visiting emergency departments due to opioid abuse, misuse, overdose, and addictions to heroin and cocaine. In

pain relieving
chronic pain
opioid
  • 0 views
  • 17 Nov, 2021
  • 2 locations
VERDICT (Veterans Response to Dosage in Chiropractic Therapy): A Pragmatic Randomized Trial Addressing Dose Effects for Chronic Low Back Pain (VERDICT)

This study evaluates how Veterans with chronic low back pain (cLBP) respond to varying doses of chiropractic therapy and how health services utilization are impacted as a result. There are 2 phases in this study. In Phase 1, half of participants will receive a low dose (1-5 visits) of chiropractic …

manipulation
chiropractic
low back pain
back pain
  • 0 views
  • 19 Oct, 2022
  • 4 locations
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (DCRI Coordinating Center) (ADOPT PGx)

This study is comprised of three separate pharmacogenetic trials grouped into a single protocol due to similarities in the intervention, the hypotheses, and the trial design. The three trials are the Acute Pain Trial, the Chronic Pain Trial, and the Depression Trial. Participants can enroll in only one of the …

pain relieving
fibromyalgia
codeine
selective serotonin reuptake inhibitors
tramadol
  • 299 views
  • 04 Oct, 2022
  • 10 locations
Combined Cryotherapy With Compression Versus Cryotherapy Alone After Orthopaedic Surgery

Cryotherapy has been used to enhance recovery after orthopaedic surgery. Many devices are available but few can guarantee a temperature regulation during a prolonged time and therefore have been criticized. The arrival of new advanced cryotherapy devices made it possible to test the effect of prolonged cooling on rehabilitation after …

  • 0 views
  • 26 Apr, 2022
  • 1 location
Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response (SCEPTER)

VETERANS ONLY. Chronic low back pain (cLBP) is common. Most Americans will have at least one episode of low back pain in their lifetimes. Approximately 50% of all US Veterans have chronic pain, and CLBP is the most common type of pain in this population. This study will use a …

  • 0 views
  • 04 Oct, 2022
  • 4 locations
Cannabidiol Pharmacotherapy for Comorbid Opioid Addiction and Chronic Pain

The overarching goal of this study is to evaluate the potential of Cannabidiol (CBD) as an adjunctive treatment for comorbid opioid use disorder (OUD) and chronic pain. This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of CBD on measures of pain and …

methadone
maintenance treatment
substance use
opioid
  • 0 views
  • 25 Oct, 2022
  • 1 location
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET

considerable potential for advancing the neurobiological understanding of human cocaine and opiate addiction.

Accepts healthy volunteers
opioid dependence
cocaine use disorder
addiction
cocaine user
  • 24 views
  • 05 Jun, 2022
  • 1 location