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Found 965 clinical trials
Long-acting Buprenorphine vs. Naltrexone Opioid Treatments in CJS-involved Adults

This study seeks to compare the effectiveness of two medications used to treat opioid use disorder, extended-release buprenorphine (XR-B) vs. extended-release naltrexone (XR-NTX), among adults

  • 24 Mar, 2022
  • 2 locations
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

This study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (Tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term pain relief and decrease the use of postoperative narcotics.

Accepts healthy volunteers
  • 24 Mar, 2022
  • 1 location
Heterodyned Whole-Body Vibration in Treatment of Opioid Withdrawal-Induced Anxiety

In this randomized, double-blind, controlled, parallel group study (conducted over 12-months), enrollment is expected of up to 60 subjects (30 men and 30 women) ages 18+ who are currently going through withdrawal of OUD and being treated at local substance abuse clinics. The study visits will include screening, baseline, Weeks …

  • 16 Mar, 2022
  • 1 location
Effects of Peripherally Acting µ-opioid Receptor Antagonists on Acute Pancreatitis

This study will investigate the effect of peripheral acting opioid antagonist (PAMORA) on the disease course of patients with acute inflammation of the pancreas (acute pancreatitis). The study

  • 13 Dec, 2021
  • 4 locations
OXD01 in Combination With Sublingual Buprenorphine/Naloxone for Treatment of Opioid Use Disorder

standard of care (SL BUP/NAL SOC) background therapy compared to SL BUP/NAL alone to change opioid use patterns in subjects with OUD. Approximately 400 subjects will be randomized. The study will

  • 09 Sep, 2021
  • 21 locations
Use of SVS Device to Improve Outcomes for Neonatal Opioid Withdrawal Syndrome.

Maternal use and addiction to opioids has resulted in an unprecedented rise in drug withdrawal complications in newborns known as neonatal opioid withdrawal syndrome (NOWS), also referred to as

  • 15 Dec, 2021
  • 1 location
Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder

Current clinical guidelines for medication assisted treatment (MAT) of opioid use disorder (OUD) recommend that treatment include a psychosocial component to help address psychological factors

narcotic use
  • 26 Jan, 2021
  • 4 locations
Extended-Release Buprenorphine vs. Sublingual Buprenorphine for the Treatment of Opioid Use Disorder

The study is 12-week, randomized, open-label study comparing injectable extended-release buprenorphine (Sublocade) to standard therapy (sublingual buprenorphine), to see if Sublocade will be more helpful in treating opiate use for individuals testing positive for fentanyl and related high potency drugs (HPSO). Those receiving Sublocade will have it administered monthly and …

  • 07 Aug, 2021
  • 1 location
Coordinating Opioid Use Treatment Through Medical Management With Infection Treatment (Project COMMIT)

This study seeks to test a new model of care (ID/LAB) in which opioid use disorder (OUD) is managed by infectious disease (ID) specialists and hospitalists concurrent with management of the OUD

  • 26 Nov, 2021
  • 3 locations
A Pilot Feasibility Study of Mindfulness-Oriented Recovery Enhancement With Pregnant Women With Opioid Use Disorder

Thirty pregnant women with substance use disorder will be recruited to participate in eight sessions of MORE.

  • 27 Apr, 2022
  • 1 location