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Found 957 clinical trials
Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries (No OUCH)

: the Opioid trial or the Non-Opioid trial. If they select the Non-opioid trial, they will have an equal chance of receiving either (a) Ibuprofen OR (b) Ibuprofen and acetaminophen. If they select the

  • 07 Feb, 2022
  • 12 locations
Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0)

Through CTN-0076-Ot (Clinical Decision Support for Opioid Use Disorders in Medical Settings: Pilot Usability Testing in an EMR (COMPUTE)), our team has iteratively developed and piloted a web

  • 08 Apr, 2022
  • 3 locations
Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)

The objective of this study is to evaluate the efficacy of a rapid wean intervention compared with a slow-wean intervention in reducing the number of days of opioid treatment from the first dose

  • 22 Mar, 2022
  • 18 locations
Adapting the HOPE Online Support Intervention to Increase Uptake of Medications for Opioid Use Disorder

In a randomized controlled trial, with 3, 6-month and 1-year follow-up, this application aims to explore whether and how the HOPE intervention can be adapted to increase MOUD uptake among OUD patients, assess the effectiveness of using HOPE to increase MOUD requests, and analyze online community data to improve future …

  • 03 Apr, 2021
  • 1 location
A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder (VA-BRAVE)

opioid treatment and in sustaining opioid abstinence compared to the daily sublingual (under the tongue) buprenorphine formulation at a target dose of 16-24 mg (standard of care). This is an open-label

  • 24 Mar, 2022
  • 16 locations
Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

This is a two phase study investigating combinations of pharmacological and behavioral interventions to optimize the treatment of Opioid Use Disorder (OUD). The Retention Phase will assess

  • 01 May, 2022
  • 17 locations
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia

including intra- and postoperative pain. The µ-opioid receptor agonists induce analgesic effect via inhibition of the transduction and the transmission of pain signals, by suppression of the release of CGRP

  • 02 May, 2022
  • 1 location
A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers

The primary hypothesis of this study is that at 3 months, there will be a higher proportion of intervention participants vs. control participants who report greater risk of harm from misuse of prescription opioids AND heroin/fentanyl.

Accepts healthy volunteers
  • 13 Nov, 2021
  • 1 location
Project MIMIC (Maximizing Implementation of Motivational Incentives in Clinics) (MIMIC)

There is an urgent need for effective treatments for patients with opioid use disorder (OUD). This study will train opioid treatment centers in an evidence-based behavioral treatment called

  • 05 Feb, 2022
  • 11 locations
Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments

/naloxone microdosing and standard dosing take-home induction regimens at enabling patients to successfully complete the induction regimen, and at retaining patients on opioid agonist therapy. We

  • 10 Aug, 2021
  • 4 locations