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Found 69 clinical trials
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A Phase 2 Study to Investigate the Safety and Efficacy of ABBV-105 and Upadacitinib Given Alone or in Combination (ABBV-599 Combination) in Subjects with Moderately to Severely Active Systemic Lupus Erythematosus

The purpose of this study is to see if the study drugs, ABBV-105, upadacitinib (ABT-494), or both ABBV-105 and upadacitinib (ABT-494) in combination (ABBV-599) are safe, tolerable, and effective in treating your moderately to severely active systemic lupus erythematosus (SLE).  

cyclosporine
prednisone
  • 155 views
  • 23 Nov, 2020
  • 1 location
Smartphones for Opiate Addiction Recovery (SOAR)

Treatments for opioid addiction exist, but effectiveness is compromised when subjects use illicit opiates during treatment. Reuse rates during treatment can be high, and reducing illicit opiate

  • 0 views
  • 20 Jun, 2022
  • 1 location
Comparative Study Between the Efficacy of The Serratus Anterior Plane Block and Lumbar Intrathecal Fentanyl Injection for Postoperative Analgesia After Modified Radical Mastectomy

, consequently, less chronic pain. They can reduce perioperative opiates requirement and thereby decreasing their possible side effects. These regional procedures include local wound infiltration, lumbar

  • 0 views
  • 17 May, 2022
  • 1 location
Methylnaltrexone vs Naloxegol in the Treatment of Opioid-Induced Constipation

The purpose of this study is to compare the efficacy of subcutaneous versus oral mu-opioid receptor antagonist therapy in opioid induced constipation that is refractory to other bowel regimens.

  • 14 views
  • 10 Apr, 2022
  • 1 location
Mindfulness-Oriented Recovery Enhancement (MORE) in Heroin Addiction

In this study, neuroimaging of reward processing, drug cue reactivity and inhibitory control is used before and immediately after 8 weeks of two types of group therapy in individuals with opioid addiction; clinical outcomes will be assessed before, immediately and three months after treatment. Results could point to factors that …

  • 0 views
  • 25 Jan, 2021
  • 1 location
A Study of Oral Ibogaine in Opioid Withdrawal

Study DMX-IB 201 is a Phase 1/2a study of ibogaine consisting of an initial single ascending dose escalation stage to determine the maximum tolerated dose (MTD) or treat-to-target dose (TTD) in healthy volunteers, followed by a randomized, double-blind, placebo-controlled proof of concept stage to demonstrate the efficacy, safety and tolerability …

Accepts healthy volunteers
  • 0 views
  • 06 Jun, 2022
  • 1 location
Counseling for Office-Based Buprenorphine

The major goal is to determine whether adding cognitive behavioral therapy to physician management will increase the efficacy of buprenorphine/naloxone treatment in an office-based primary care setting.

buprenorphine
drug use
  • 48 views
  • 07 Nov, 2020
  • 1 location
The IPLA-OVCA Trial, Intra-Peritoneal Local Anaesthetics in Ovarian Cancer (IPLA-OVCA)

Surgery and chemotherapy combined constitute first line treatment in women with advanced ovarian cancer. The aim of surgery apart from staging is cytoreduction, i.e. surgical resection of tumour. Radical resection of all tumour visible by the naked eye followed by adjuvant chemotherapy is associated with best chance of prolonged survival. …

surgery for ovarian cancer
metastasis
ovarian cancer stage
cancer of the ovary
cytoreductive surgery
  • 0 views
  • 30 Jun, 2022
  • 1 location
Comparing Home Office and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder

HOMER is a national study comparing three methods of induction for Medication Assisted Treatment (MAT) for Opioid Use Disorder (OUD); home versus office versus telehealth-based inductions. This study will help determine if certain patient and practice characteristics make patients better candidates for one method over the others. Results will help …

opioid use disorder
opioid
morphine
addiction
buprenorphine
  • 27 views
  • 31 Jul, 2021
  • 2 locations
Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support (TCN-PATHS)

TCN PATHS will recruit 800 people who are prescribed MOUD who are released from 8 detention facilities. Each individual will be randomized to either 1) standard primary care (SPC) or 2) a Transitions Clinic Network (TCN) program primary care. Participants will be followed for a year and complete surveys at …

naltrexone
opioid
addiction
buprenorphine
methadone
  • 18 views
  • 06 Jun, 2022
  • 2 locations