Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 34 clinical trials
None
Abemaciclib in Patients With Oligodendroglioma

This is a phase II, single arm, open label study looking how well a drug called abemaciclib works in patients with recurrent oligodendroglioma

neutrophil count
MRI
karnofsky performance status
glomerular filtration rate
nitrosoureas
  • 7 views
  • 15 May, 2021
  • 1 location
None
Pediatric Long-Term Follow-up and Rollover Study

A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.

trametinib
dabrafenib
  • 487 views
  • 28 Apr, 2021
  • 17 locations
None
Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas

enroll patients with histologically confirmed high-grade gliomas to evaluate the ability of regadenoson to transiently disrupt a relatively intact blood-brain barrier (BBB). determine the best dose of regadenoson to disrupt the BBB and allow for enhanced penetration of gadolinium during MRI.

oligodendroglioma
glioblastoma multiforme
astrocytoma
erlotinib
gliosarcoma
  • 3 views
  • 18 Sep, 2021
  • 9 locations
None
Implantable Microdevice In Primary Brain Tumors

This pilot study will assess the safety and feasibility of using an implantable microdevice to measure local intratumor response to chemotherapy and other clinically relevant drugs in malignant brain tumors. The device involved in this study is called a microdevice. The drugs used in this study will only include drugs …

neutrophil count
glioblastoma multiforme
oligodendroglioma
primary brain neoplasm
astrocytoma
  • 4 views
  • 28 Feb, 2021
None
Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

This is a safety (Phase 1) trial using mebendazole for recurrent pediatric brain cancers that include medulloblastoma and high grade glioma, that are no longing responding to standard therapies. The drug mebendazole is an oral drug in a chewable 500 mg orange flavored tablet. It is already approved to treat …

medulloblastoma
neutrophil count
mebendazole
malignant brain tumor
treatment regimen
  • 206 views
  • 30 Sep, 2021
  • 2 locations
None
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

This is a multicenter phase 1 trial of INCB7839 for children with recurrent or progressive high-grade gliomas, including, but not limited to, diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs), after upfront therapy.

astrocytoma
dexamethasone
MRI
sargramostim
antiretroviral agents
  • 0 views
  • 01 Oct, 2021
  • 11 locations
None
Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma

Low-grade glioma (LGG) is a common primary brain tumor in young adults. The infiltrative nature and frequent growth in eloquent area in brain often makes total resection impossible. Until now, no agreement has been achieved on the treatment of LGG without total resection. Post-radiation adjuvant temozolomide (TMZ) is currently the …

oligodendroglioma
primary brain neoplasm
astrocytoma
primary brain tumors
brain tumor
  • 27 views
  • 24 Jan, 2021
  • 1 location
None
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

This randomized phase II clinical trial studies the side effects and how well proton beam or intensity-modulated radiation therapy works in preserving brain function in patients with IDH mutant grade II or III glioma. Proton beam radiation therapy uses tiny charged particles to deliver radiation directly to the tumor and …

neutrophil count
beam radiation
oligodendroglioma
karnofsky performance status
astrocytoma
  • 38 views
  • 23 Sep, 2021
  • 14 locations
None
Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors

By employing a combination of advanced MRI techniques and correlative serum biomarkers of blood brain barrier (BBB) disruption, the investigators plan to develop a powerful, first of its kind clinical algorithm in pediatrics whereby the investigators can measure and identify the window of maximal BBB disruption post MLA to 1) …

neutrophil count
anthracycline
recurrent tumor
tumor progression
anthracyclines
  • 28 views
  • 24 Mar, 2021
  • 1 location
None
Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma

This is a pilot neoadjuvant vaccine study in adults with WHO grade II glioma, for which surgical resection of the tumor is clinically indicated. Co-primary objectives are to determine: 1) the safety and feasibility of the neoadjuvant approach; and 2) whether the regimen increases the level of type-1 chemokine CXCL10 …

corticosteroids
oligodendroglioma
karnofsky performance status
astrocytoma
poly-iclc
  • 111 views
  • 12 Jun, 2021
  • 1 location