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Found 38 clinical trials
RCT of Olanzapine for Control of CIV in Children Receiving HSCT Conditioning

cell transplant (HSCT) conditioning experience CINV despite receiving antiemetic prophylaxis. Olanzapine improves CINV control in adult cancer patients, has a track record of safe use in children with

cancer
granisetron
olanzapine
ondansetron
vomiting
  • 2 views
  • 13 Feb, 2021
  • 1 location
Efficacy and Safety of Olanzapine for the Treatment of Nausea and Vomiting in Palliative Cancer Care

Oral olanzapine showed superior antiemetic efficacy to metoclopramide as rescue treatment to control breakthrough emesis induced by chemotherapy. This study aims to evaluate safety and efficacy

advanced cancer
cancer
olanzapine
metoclopramide
vomiting
  • 3 views
  • 22 Jan, 2021
  • 1 location
Molecular Mechanisms of Antipsychotic-induced Insulin Resistance

This study will investigate the molecular mechanisms of atypical-antipsychotic induced insulin resistance. This will be accomplished by administering olanzapine or placebo to healthy subjects

  • 17 views
  • 25 Jan, 2021
  • 1 location
Study Evaluating the Safety Efficacy and Pharmacokinetics of Miricorilant in Obese Adult Patients With Schizophrenia While Taking Antipsychotic Medications (GRATITUDE II)

This Phase 2, double-blind, placebo-controlled, randomized study is to assess the safety and efficacy of miricorilant (CORT118335) in obese patients with schizophrenia treated with antipsychotic medications.

  • 0 views
  • 27 Jan, 2021
  • 17 locations
Switching From Twice-Daily to Once-Daily Clozapine Dosing in Schizophrenia

Plasma half-life has routinely been used to establish the dosing schedule of antipsychotics; for example, it is recommended that agents with a short plasma half-life be administered multiple times per day. However, to date, several randomized controlled trials (RCTs) have shown no differences in clinical outcomes between once- and twice-daily …

antipsychotics
schizoaffective disorder
clozapine
schizophrenia
  • 123 views
  • 24 Jan, 2021
  • 1 location
Effect of Vortioxetine on Cognitive Symptoms in Patients With Schizophrenia

Research goals: Examination of the relationship between the use of vortioxetine and cognitive efficacy in patients with schizophrenia. Examination of the association between the use of vortioxetine and the presence depressive symptoms, physical and social anhedonia in patients with the disease from schizophrenia. Examining the association between vortioxetine use and …

antipsychotics
risperidone
schizophrenia
vortioxetine
  • 0 views
  • 24 Jan, 2021
  • 1 location
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder

The investigators will test the hypothesis that inhaled xenon will produce a rapid improvement in depressive symptoms in patients suffering from treatment-resistant depression. Specifically, the investigators will conduct a parallel randomized, double-blind crossover study that will compare the effects of xenon-oxygen (35:65 ratio by volume) added to treatment as usual …

antidepressants
depressive symptoms
depression
depressed mood
depressive disorder
  • 54 views
  • 23 Jan, 2021
Bromocriptine for Patients With Schizophrenia and Impaired Glucose Tolerance

This is a multicenter open-label, pilot study to evaluate the safety and tolerability of bromocriptine, a dopamine D2/D3 receptor and serotonin 5-HT2C receptor agonist, as an adjunct to preexisting standard-of-care antipsychotic drug (APD) regimens in the management of APD-associated impaired glucose tolerance (IGT)/insulin resistance (IR). The ultimate aim of the …

antipsychotics
insulin resistance
drug abuse
dopamine
impaired glucose tolerance
  • 0 views
  • 24 Jan, 2021
  • 1 location
Selinexor With Multiple Standard Chemotherapy or Immunotherapy Regimens in Treating Patients With Advanced Malignancies

This phase Ib trial studies the side effects and best dose of selinexor when given together with several different standard chemotherapy or immunotherapy regimens in treating patients with malignancies that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced). Selinexor may …

neutrophil count
solid tumors
growth factor
irinotecan
oxaliplatin
  • 14 views
  • 24 Feb, 2021
  • 9 locations
Saxenda in Obese or Overweight Patients With Stable Bipolar Disorder (Investigator Initiated)

Taken together these data support the hypothesis that liraglutide 3.0 mg sc injection will reduce body weight and improve metabolic variables in obese or overweight patients with BP without worsening psychiatric symptoms. The investigators predict that liraglutide 3.0 mg sc injection will display greater efficacy as compared to placebo in …

antipsychotics
schizoaffective disorder
antidepressants
liraglutide
psychotropic drugs
  • 525 views
  • 25 Jan, 2021
  • 1 location