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Found 6 clinical trials
Neoadjuvant/Adjuvant Trial of Darovasertib in Ocular Melanoma (NADOM)

The purpose of this study is to determine the feasibility and tolerability of neo-adjuvant/adjuvant Darovasertib on uveal melanoma patients. Who is it for? Patients may be eligible to join this study with high-risk uveal melanoma and planned to undergo enucleation Study details: Eligible patients will undergo up to 4 weeks …

  • 0 views
  • 10 May, 2022
  • 1 location
Melanoma Vaccine Against Neoantigen and Shared Antigens by CD40 Activation and TLR Agonists In Patients With Melanoma (Including Ocular Melanoma) (Mel66)

This study evaluates whether it is safe to administer a peptide vaccine made of 6MHP and a mutated neoantigen peptide (BRAF585-614-V600E) combined with adjuvants. The adjuvants that will be used in this trial are a CD40 antibody (CDX-1140) and a toll-like receptor (TLR) 3 agonist (Poly-ICLC). The study will also …

immunomodulators
immunologic adjuvant
brain metastases
metastasis
peptide vaccine
  • 0 views
  • 11 May, 2022
  • 3 locations
Phase 2 Trial to Evaluate Safety and Efficacy of AU-011 Via Suprachoroidal Administration in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma

The primary objective is to assess safety and efficacy of AU-011 via suprachoroidal injection to treat primary indeterminate lesions and small choroidal melanoma.

metastasis
choroid melanoma
  • 0 views
  • 22 Apr, 2022
  • 18 locations
Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca

the neratinib and sodium valproate combination in advanced solid tumors with attention to RAS-mutated tumors, EGFR-altered GBM, and ocular melanoma, as part of the phase 2 expansion cohort.

cancer
aptt
ejection fraction
alopecia
metastasis
  • 14 views
  • 13 Mar, 2022
  • 1 location
A Study to Assess PV-10 Chemoablation of Cancer of the Liver

This open-label study will evaluate the safety, tolerability, pharmacokinetics and effect on tumor growth following a single intralesional injection of PV-10 in subjects with either (a) hepatocellular carcinoma (HCC) that is not amenable to resection, transplant or other potentially curative therapy or (b) cancer metastatic to the liver.

cancer
spiral computed tomography
platelet count
renal function test
karnofsky performance status
  • 177 views
  • 05 Apr, 2022
  • 1 location
A Prospective Natural History Study in Uveal Melanoma

The overall objective of this proposal is to develop and utilize a multicenter UM registry that will, in a longitudinal fashion, capture prospective data in order to characterize the natural history of UM and provide data that will be used to support the development of novel therapies for this disease. …

  • 0 views
  • 25 Mar, 2021
  • 2 locations