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Found 25 clinical trials
Phenotype Identification Based on Multimodal MRI Analysis of Patients With Bronchial Obstructive Diseases (PIMABOD)

The hypothesis is that pulmonary and cardiac proton MRI allows phenotyping of patients with bronchial obstruction by cluster analysis based on quantitative multimodal imaging of bronchi, pulmonary vessels, pulmonary parenchyma, right and left ventricular function, myocardial fibrosis and pulmonary arterial pressure. Such imaging will also offer the advantage of being …

  • 0 views
  • 04 Jun, 2022
  • 6 locations
Multivessel TALENT

Multivessel TALENT is a prospective, randomized, multi-center study comparing clinical outcomes between SUPRAFLEX Cruz and SYNERGY in approximately 1550 patients with de-novo three vessel disease undergoing percutaneous coronary intervention (PCI). Patients will be treated according to "state of art PCI"; not only treatment strategies based on the latest ESC guideline, …

prasugrel
antiplatelet therapy
cholesterol measurement
stenosis
percutaneous coronary intervention
  • 0 views
  • 09 May, 2022
  • 1 location
Dual Anti-Platelet Therapy in Patients With Coronary Multi-Vessel Disease (DAPT-MVD)

This study is a prospective, multicenter, parallel, open-label, randomized, controlled, superiority trial. It is planned to recruit 8,250 patients with multi-vessel disease(MVD), and the patients will be followed-up for 12 months after being implanted with a drug-eluting stent (DES) at one of 100 different centers. All patients will be randomly …

clopidogrel
dapt
aspirin
antiplatelet therapy
  • 0 views
  • 02 May, 2022
  • 88 locations
High-Flow Nasal Oxygen Therapy for Exacerbation of Chronic Pulmonary Obstructive Disease.

High-Flow Nasal Oxygen (HFNO) therapy has never been tested against Noninvasive ventilation, the reference standard therapy for acute exacerbation of chronic obstructive pulmonary disease (COPD), in randomized clinical trials. The aim of the present study is to compare the effects of HFNO therapy on arterial blood gas variables over the …

carbon dioxide
acute exacerbation of chronic obstructive pulmonary disease
arterial blood gases
non-invasive ventilation
  • 33 views
  • 02 Nov, 2021
  • 3 locations
Ischemia in Patients With Non-obstructive Disease (INOCA) in Italy INOCA IT Multicenter Registry" (INOCAIT)

Prospective, interventional, multicentre, non-randomized, single-arm open-label study that aims to enroll 200 consecutive patients with suspected chronic ischemic heart disease in the absence of obstructive coronary artery disease (INOCA) at clinically indicated coronary angiography in 3 Italian centers. During coronary angiography, these patients will be simultaneously subjected to a functional …

angiography
stenosis
heart disease
ischemia
  • 0 views
  • 24 Mar, 2022
  • 1 location
Paclitaxel Eluting Stent in Long SFA Obstruction: A Prospective, Randomized Comparison With Bypass Surgery (finnptx)

Chronic lower limb ischemia due to atherosclerosis causes significant morbidity especially in elderly: the prevalence of asymptomatic obstructive peripheral atherosclerosis among 40-74 old is 4-22%. The prevalence of its milder symptomatic manifestation, intermittent claudication among 40 years old men is about 1% and among 70 years old it is 7%. …

balloon angioplasty
ischemia
paclitaxel
atherosclerosis
limb ischemia
  • 33 views
  • 06 Jun, 2022
  • 1 location
Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia (NL003-CLI-III-2)

The purpose of this study is to evaluate whether intramuscular injections of NL003 into the calf is safe and effective in the treatment of critical limb ischemia

critical limb ischaemia
ischemia
limb ischemia
gangrene
stenosis
  • 2 views
  • 20 Apr, 2022
  • 12 locations
Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia (NL003-CLI-III-1)

To evaluate the safety and efficacy of recombinant human hepatocyte growth factor (HGF) bare plasmid injection for local intramuscular injection in the treatment of patients with severe lower limb hemorrhagic disease (Rutherford grade 4)

stenosis
critical limb ischaemia
hepatocyte growth factor
ischemia
gene therapy
  • 9 views
  • 22 Apr, 2022
  • 11 locations
The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD

MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association with mitochondrial function, oxidative metabolism, walking distances and quality of life. The protocol evaluates the mechanisms which …

critical limb ischaemia
ischemia
peripheral arterial diseases
Accepts healthy volunteers
arteriopathy
  • 16 views
  • 16 Mar, 2022
  • 2 locations
A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation (CHAMP)

Patients undergoing semi-elective lower extremity major amputation from complications associated with atherosclerotic limb ischemia will received intra-muscular injections of allogeneic Mesenchymal Stromal Cells in the leg above and below the point of amputation to prevent ischemic wound complications after surgery and decrease the incidence of revision and further amputation.

gangrene
ischemic wound
ischemia
limb ischemia
  • 49 views
  • 25 Feb, 2022
  • 1 location