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Found 1067 clinical trials
CBF and Childhood OSAS

Obstructive sleep apnea syndrome (OSAS) causes hypoxemia and hypercapnia, which may impair cerebral blood flow and cause deficits in behavior. This is a case-control study designed to investigate cerebral blood flow and neurocognitive function in children with OSAS when compared to these findings from normal children. The study hypothesis is …

obstructive sleep apnea
continuous positive airway pressure
  • 28 Jan, 2021
  • 1 location
COPD-Related Physiology and the Brain

COPD is the third leading cause of combined morbidity, disability, and mortality in the United States and is often associated with cognitive impairment. The goal of the proposed project is to examine novel pulmonary and vascular physiological mechanisms that contribute to structural brain abnormalities and cognitive dysfunction early in the …

neuropsychological test
  • 26 Feb, 2021
  • 1 location
The Pathogenesis of OSA in People Living With HIV

The purpose of this study is to help us understand how HIV and/or Anti-Retroviral Therapy (ART) may predispose individuals to Obstructive Sleep Apnea (OSA). The traditional risk factors for OSA are weight and age. However, people living with HIV on ART seem to have OSA even when they are thin …

antiretroviral therapy
continuous positive airway pressure
  • 26 Jan, 2021
  • 1 location
Could HRV be a Valuable Predictor for CPAP Adherence?

This study aim to evaluate if the improvement of heart rate variability for the continuous positive airway pressure titration night can predict the short and long term continuous positive airway pressure adherence for patients with moderate to severe OSA.

apnea-hypopnea index
continuous positive airway pressure
  • 22 Jan, 2021
  • 2 locations
Sacral Neuromodulation and Pudendal Somatic Afferents

Sacral neuromodulation is a well-excepted minimally invasive procedure for the treatment of overactive bladder and non-obstructive urinary retention.A tined lead with 4 stimulation electrodes is placed through the third or fourth sacral foramen and stimulates sacral roots in its vicinity. Since the sacral roots are mixed nerves, it is currently …

  • 23 Jan, 2021
Obstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living With HIV

The investigators seek to understand how the different underlying causes of OSA affect the way people living with HIV (PLWH) experience OSA. The investigators also want to understand how symptoms of obstructive sleep apnea improve with treatment, and if this too, is affected by the underlying cause of OSA in …

HIV Vaccine
  • 26 Jan, 2021
  • 1 location
Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation

While thoracic radiation therapy (TRT) has been a primary component in successful treatment of Hodgkin lymphoma, exposure to this treatment has been associated with significant cardiovascular, cerebrovascular, and pulmonary morbidity in long-term survivors. Survivors of Hodgkin lymphoma (HL) are also at risk for fatigue and excessive daytime sleepiness. Insufficient sleep …

excessive daytime sleepiness
body mass index
  • 16 Feb, 2021
  • 1 location
A Study of Smoking Cessation Patterns in Participants Undergoing Lung Surgery

The purpose of this study is to assess the current smoking status and smoking cessation attempts among smokers or recent smoking quitters during the perioperative period, to describe postoperative pulmonary complications (PPCs) and other postoperative complications (PCs) following a lung surgery, and to describe the smoking cessation methods and services …

lung operation
lung cancer
lung surgery
  • 11 Apr, 2021
  • 3 locations
Evaluating the Alimentary and Respiratory Tracts in Health and Disease (EARTH) Research Program.

The investigators have established the "Evaluating the Alimentary and Respiratory Tracts in Health and disease" (EARTH) research program. It provides a structured approach to analysing gastrointestinal and respiratory microbiomes, along with diet and symptomatology, in children with a gastrointestinal and/or respiratory condition with recognised long-term morbidity (e.g. cystic fibrosis, obstructive …

  • 23 Jan, 2021
  • 1 location
Role of MRI Defecography in Diagnosis of Obstructed Defecation Syndrome

The aim of the study was to assess the advantages of dynamic magnetic resonance imaging defecography to elucidate the underlying anatomic and pathophysiologic background in obstructed defecation patients to guide physicians in patient management.

  • 24 Jan, 2021
  • 1 location