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Found 71 clinical trials
Effect of Hemp-CBD on Patients With CIPN

The purpose of this study is to assess the effect of a hemp-based cannabidiol (CBD) product, Ananda Hemp Spectrum Gelcaps, on the severity and duration of chemotherapy-induced neuropathy (CIPN) among non-metastatic breast, colorectal, uterine and ovarian cancer patients who received neoadjuvant or adjuvant therapy that included neurotoxic chemotherapeutic agents.

cancer chemotherapy
stage iv breast cancer
ovarian cancer
  • 25 Jan, 2021
  • 1 location
The Optimal Time of IV Dexamethasone Administration for Prolongation of Peripheral Nerve Block

The purpose of this study is to determine the optimal timing of IV dexamethasone for prolongation of ultrasound (US) guided supraclavicular brachial plexus block (SCB) in patients undergoing unilateral hand or forearm surgery at the Toronto Western Hospital. Investigators seek to answer which timing of IV dexamethasone will provide the …

  • 24 Jan, 2021
  • 1 location
The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients.

Glucocorticoids are well known for their analgesic, anti-inflammatory, immunomodulatory and anti-emetic effects. Recovery time after thyroid surgery may depend on several factors, such as postoperative pain, nausea and vomiting, postoperative sore throat, voice disorders and symptomatic hypocalcaemia (low serum calcium level). However, there is little information in the literature about …

oral dexamethasone
blood tests
postoperative pain
  • 27 Jan, 2021
  • 1 location
Laparoscopic Groin Hernia Repair by a 3D ENDOLAP Visible Mesh With or Without LiquiBand Fix 8 Mesh Fixation

This study aims to visualize the implanted mesh in vivo by MRI in 20 patients at 1 month and 12 months post-operatively. Moreover, we want to evaluate the safety and efficiency of non-penetration mesh fixation techniques using pre-designed ENDOLAP 3D visible mesh placement versus mesh fixation using a synthetic LiquiBand …

unilateral inguinal hernia
  • 25 Jan, 2021
  • 1 location
A Comparison of Scar Infiltration Scar Deactivation and Standard of Care for the Treatment of Chronic Post-Surgical Pain After Cesarean Section

To compare scar infiltration with 0.5-1% Lidocaine at a dose of 3 mg/kg (max dose 300 mg) or scar deactivation with acupuncture surface release technique to determine which is more effective in reducing pain in adult patients with chronic, post-surgical pain related to the site of incision after low transverse …

back pain
  • 25 Jan, 2021
  • 1 location
Home-Based Physical Activity Intervention for Taxane-Induced CIPN

This two-group, randomized control trial (RCT) will test the effects of a home-based, 16 week gait/balance training plus resistance (exercise bands) exercise program as compared to an educational cancer survivorship attention control condition to address persistent taxane-induced peripheral neuropathy in 312 patients treated for invasive breast cancer with taxanes at …

  • 26 Jan, 2021
  • 1 location
Computer - Controlled Intraligamentary Local Anaesthesia In Extraction of Primary Molars

Background: Exodontia poses a psychological threat for children, increasing the need for profound local anesthesia to assure painless extraction and maintain child cooperation on the dental chair. Computer-controlled Intraligamentary anesthesia (CC-ILA) affects only the tooth to be treated with minimal pressure, eliminating the side effects of other conventional techniques. Purpose …

  • 25 Apr, 2021
  • 1 location
NR in Chemo-induced Peripheral Neuropathy

The purpose of this single-arm phase II trial is to determine whether nicotinamide riboside (NIAGEN) prevents the progression of peripheral sensory neuropathy in patients receiving infusions of paclitaxel or nab-paclitaxel for the treatment of metastatic breast cancer or recurrent platinum-resistant ovarian, endometrial, peritoneal, or fallopian tube cancer.

monoclonal antibodies
  • 03 May, 2021
  • 3 locations
Intravenous Lignocaine Infusion in Laparoscopic Donor Nephrectomy

Background Administration of morphine as boluses or via a patient controlled analgesic device (PCA) has been the standard practice for donors after nephrectomy. However, administration of morphine is far from being ideal analgesic as it does not provide optimal dynamic pain relief after major surgery, consistently demonstrate little effect on …

pain relief
postoperative pain
  • 25 Jan, 2021
  • 1 location
tDCS and Pain Associated With Diabetic Neuropathy

The purpose of this study is to investigate the effects of anodal transcranial direct current stimulation (tDCS) on pain intensity associated with diabetic neuropathy. The investigators will conduct real tDCS or sham, over the left dorsolateral prefrontal cortex (DLPFC) during 6 separated days. They will evaluate pain intensity, sleep quality, …

depressive symptoms
transcranial direct current stimulation
diabetic neuropathy
chronic pain
  • 25 Jan, 2021
  • 1 location