Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 92 clinical trials
The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease

Interstitial lung disease (ILD) is the result of over 200 etiological pathways arising from several different insults to the lung parenchyma: inhaled substances, drug side effects, connective tissue disease, infection, and malignancy. The disease can also be of idiopathic origin. If prolonged, the resulting inflammation causes permanent and progressive fibrotic …

sarcoidosis
hypertension
fibrosis
pulmonary rehabilitation
pulmonary fibrosis
  • 81 views
  • 28 Jun, 2022
  • 3 locations
Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation (RAFT-PermAF)

Atrial fibrillation (AF) and heart failure (HF) are two common heart conditions that are encountered with an increase in death and suffering. When both these two conditions occur in a patient, the patient's prognosis is poor with a reduced quality of life and impaired heart function. These patients have enlarged …

dyspnea
secondary prevention
cardiac death
permanent atrial fibrillation
heart failure
  • 77 views
  • 11 Apr, 2022
  • 13 locations
Balloon Pulmonary Angioplasty in Non-operable CTEPH Patients

Balloon pulmonary angioplasty (BPA) emerged as a potential therapeutic option for non-operable patients with chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this study was to evaluate the safety and efficacy of BPA in patients disqualified from surgery or suffered from persistent CTEPH despite pulmonary endarterectomy. This is a interventional …

endarterectomy
  • 1 views
  • 29 Aug, 2021
  • 1 location
Myocardial Contrast Echocardiography in Septic Patients

Myocardial microcirculatory alterations may be involved in the pathogenesis of acute cardiac dysfunction or septic cardiomyopathy in septic patients. The investigators study the cardiac function (systolic and diastolic) with two-dimensional echocardiography (TTE), and the myocardial microcirculation with contrast echocardiography (MCE) and sulphur hexafluoride microbubbles Sonovue injection in ICU septic patients.

resuscitation
organ failure
lactate level
dysregulated host response
shock
  • 0 views
  • 25 Jan, 2021
  • 1 location
Comparison of BTD and BCD Based Regimens in the Treatment of AL Amyloidosis

Research Objective:At present, there is no standard therapeutic regimen for monoclonal immunoglobulin light chain (AL) amyloidosis in the world. To compare the efficacy and safety of the regimens between bortezomib-thalidomide-dexamethasone (BTD) and bortezomib-cyclophosphamide-dexamethasone (BCD) in the treatment of AL amyloidosis, so as to provide more clinical evidence for the standard …

cyclophosphamide
immunoglobulin
dexamethasone
bone marrow procedure
thalidomide
  • 0 views
  • 26 Jan, 2021
  • 1 location
Breathing Exercise Against Dyspnoea in Heart Failure Patients to Improve Chemosensitivity (Breathe-HF)

An exaggerated ventilatory response (minute ventilation, V̇E) to exercise relative to exhaled carbon dioxide (V̇CO2) is common in heart failure (HF) patients with reduced as well as preserved left ventricular ejection fraction (HFrEF, HFpEF). Severity of this exaggerated response is associated with poor prognosis. This response may be triggered by …

dyspnea
medical therapy
congestion
ejection fraction
heart failure
  • 0 views
  • 18 Apr, 2022
Cancer Adverse Effects PReventIon With Care & Exercise: the CAPRICE Study

Breast cancer is the most common cancer among women worldwide. Similarly, Hodgkin and nonHodgkin lymphomas make up two of the most prevalent cancers in men and women. Even though remarkable improvements in cancer-free survival have been achieved in the last decades, the development of cardiac toxicity, associated with anthracycline-based chemotherapy …

anthracyclines
chemotherapy regimen
adjuvant therapy
hodgkin's disease
myocardial injury
  • 5 views
  • 29 May, 2022
  • 4 locations
Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis

Approximately 40,000 Swedes suffer from sepsiseach year, about 20% die. Biomarkers that are sensitive to current or previous bacteremia are needed in the treatment of sepsis. Bacteremia from periodontal treatment is predictive and occurs in 13-75%. The study's hypothesis is to utilize bacteremia from periodontal treatment to evaluate biological markers …

antimicrobial agent
antibiotics
Accepts healthy volunteers
bacteremia
antimicrobials
  • 2 views
  • 19 Apr, 2022
  • 1 location
Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF.

Chagas disease is considered by the World Health Organization (WHO) as one of the most neglected tropical diseases in the world, having relevance in many Latin America countries. In addition, it already affects North America, Europe, Asia and Oceania. Some studies suggest that chagasic heart failure has a worse prognosis, …

  • 0 views
  • 15 May, 2021
  • 1 location
A Study of Pulmonary Arterial Hypertension Participants Treated With Macitentan or Selexipag (INSPECTIO)

Functional Class (WHO/FC), 6-minute walk distance (6MWD), Brain Natriuretic Peptide (BNP) or N-terminal pro-brain Natriuretic Peptide (NT-proBNP).

  • 2 views
  • 30 Jun, 2022
  • 27 locations