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Found 92 clinical trials
Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery

The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients undergoing non-cardiac vascular surgery.

Accepts healthy volunteers
cardiac operation
  • 09 Oct, 2021
  • 1 location
Telotristat Ethyl for the Treatment of Carcinoid Heart Disease in Patients With Metastatic Neuroendocrine Tumor

This phase III trial compares the effect of telotristat ethyl and the current standard of care somatostatin analog therapy or somatostatin analog therapy alone in treating patients with neuroendocrine tumor that has spread to other places in the body (metastatic). Telotristat ethyl and somatostatin analog therapy may help to control …

  • 29 Aug, 2021
  • 1 location
Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH (RIVERII)

This is an open-label, single-armed, prospective single-centre clinical study to evaluate the effect of riociguat on right heart size and function in patients with manifest PAH and CTEPH.

  • 29 Apr, 2022
A Feasibility Non-inferiority Clinical Trial for Dosing of Diuretics in CHF Patients

Patients with heart failure are frequently hospitalized, have a reduced quality of life and face a higher risk of death. Much of the morbidity and reduced quality of life associated with CHF is related to symptoms of volume overload. Loop diuretics are a mainstay in the management of volume overload …

  • 24 May, 2022
  • 1 location
Implementing Standards of Care for Heart Failure Patients in General Practice - A Regional Disease Management Program

Heart failure (HF) is an important health problem. Most chronic HF management occurs in primary care. Although guidelines exist, there is an important implementation gap in current HF care in Belgium. We will conduct a non-randomized, non-controlled prospective observational trial to implement guideline-recommended best clinical practices in primary care in …

natriuretic peptide
heart failure
  • 03 Mar, 2022
Dexamethasone Versus Prednisone in Heart Failure Patients Hospitalized With Exacerbation of Chronic Obstructive Pulmonary Disease.

This is the first study assessing the impact of dexamethasone (a glucocorticosteroid with negligible mineralocorticoid activity) as compared to prednisone on short-term outcomes of HF patients hospitalized with exacerbation of COPD. The study may provide important data regarding a simple but potentially robust intervention among large patient population with high …

copd exacerbation
heart failure
  • 02 Apr, 2021
  • 1 location
Effective Study of ARNI on Ventricular Arrhythmia in HFrEF Patients With ICD or CRT-D

The purpose of this study is to generate effectiveness data of ARNI, in the Chinese HFrEF patients with implanted ICD or CRT-D. This will be a multicenter, interventional, open-label, and prospective single-arm study to evaluate the effect of ARNI on VAs in approximately 275 HFrEF patients receiving ICD or CRT-D …

angiotensin ii receptor antagonists
  • 13 Dec, 2021
  • 21 locations
Empagliflozin and Cardiac Remodelling in People Without Diabetes

The purpose of this study is to evaluate the effects of empagliflozin on cardiac structure, function and circulating biomarkers in patients with cardiovascular risk factors, but without diabetes. Empagliflozin is an antihyperglycemic agent approved by Health Canada and the FDA for the treatment of type 2 diabetes. Previous post-marketing clinical …

heart disease
myocardial infarction
antihypertensive drugs
  • 26 Jun, 2021
  • 4 locations
activeDCM - Interventional Clinical Trial of Individualized Activity and Exercise Programs to Improve Outcome in Dilated Cardiomyopathy Guided by Longitudinal Biosensing With Apple Watch (ACTIVE-DCM)

The influence of an individualized sports program on dilated cardiomyopathy patients will be investigated in a randomized, prospective intervention study. 300 patients with dilated cardiomyopathy are included and examined over a period of 13 months. All participants will receive an Apple Watch, which serves for monitoring of activity and symptoms.The …

  • 02 Jun, 2022
  • 1 location
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3

This is a double-blind, randomized, two x two crossover (aprepitant vs placebo) during both initiation of Entresto, LCZ696, (50 mg dose) and at steady-state of Entresto (200 mg bid dose or the highest tolerated dose).

b-type natriuretic peptide
natriuretic peptide
  • 15 Jun, 2022
  • 1 location