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Found 37 clinical trials
A Randomized Controlled Trial of Geriatric Emergency Department Innovations

This study evaluates the Geriatric Emergency Department Innovations (GEDI) program at Northwestern Memorial Hospital to care for older adults in the emergency department. Half of the patients will be cared for by a standard ED team plus the GEDI team, while half of the patients will receive usual ED care.

  • 08 Apr, 2022
  • 1 location
Electroceutical Dressing Technology (EDT) Against Wound Microbial Biofilm Infection (EDT BioFilm)

There are currently limited treatments available that show anti-biofilm efficacy for wound infection management Biofilms account for over 80% of infections and approximately 65% of nosocomial

  • 16 Mar, 2022
  • 3 locations
Optimization of VIM Targeting in Essential Tremor Surgery (Opti-VIM)

Deep brain stimulation (DBS) for essential tremor is based on the intermedius ventralis nucleus of the thalamus (VIM) stimulation. This structure is however very difficult to target, as it remains invisible on imaging. The current procedure based on awake surgery with clinical and electrophysiological testings has several limitations that lead …

brain stimulation
  • 14 May, 2022
  • 2 locations
Improve the Patients' Recovery With Family- Caregivers to End Delirium

This research is being done to find out if patients and caregivers who use the iPREPARED mobile health technology experience less delirium, a type of acute confusion, and if they do experience delirium, the delirium will be less severe and distressful. iPREPARED prepares patients and caregivers on what to expect …

Accepts healthy volunteers
  • 30 Dec, 2021
  • 1 location
Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH) (MATCH)

The purpose of this study is to determine whether Fecal Microbiota Therapy (FMT) is effective vs. placebo in the prevention of C. difficile infection recurrence.

antibiotic therapy
toxic megacolon
  • 07 Feb, 2022
  • 1 location
Combined Air-plasma Flow and Nitric Oxide Therapy in Cardiac Surgery

In cardiovascular surgery, the most common and serious complication is postoperative wound infection. The most formidable wound complication is mediastinitis, the frequency of which varies from 1 to 3%. Currently, mortality in this group of patients varies from 3.5 to 58.3%. In this regard, the relevance of developing new methods …

  • 21 Mar, 2022
  • 1 location
Early Diagnosis of Native and Device-associated Meningitis

Device-associated meningitis is a severe complication after implantation of various central nervous system (CNS) devices such as ventriculoperitoneal (VP) and ventriculoatrial (VA) shunts, external ventricular drains (EVD), lumbar drains (ELD) and intrathecal pumps. In contrast to native meningitis, these infections are hard to diagnose both clinically and on the laboratory …

  • 14 Dec, 2021
  • 2 locations
Conservative Versus Conventional Oxygen Administration in Critically Ill Patients

Oxygen supplementation in the inspired mixture is commonly used in critically ill patients and observational studies highlight that those patients remain hyperoxemic for substantial periods during Intensive Care Unit stay. However, exposure to inhaled oxygen-enriched mixtures is widely recognized as potentially harmful and cause of organ damage. Although, the specific …

oxygen saturation
critical illness
mechanical ventilation
  • 21 Feb, 2022
  • 1 location
Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery

This international, multicentre, pragmatic, double-blind, placebo-controlled, randomised trial of TxA versus placebo will enrol 3,300 patients throughout Australia and internationally. This is an effectiveness trial - some elements of the trial are deliberately left to the perioperative clinicians' discretion in order to reflect usual practice and maximise generalisability.

  • 28 Jan, 2021
  • 1 location
ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock (ICITRU)

Immunonutrition in intensive care has not yet demonstrated a beneficial effect on organ failure, the acquisition of nosocomial infections, or mortality. It did not correct for acquired

severe sepsis
septic shock
organ failure
mechanical ventilation
  • 20 Jun, 2022
  • 5 locations