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Found 118 clinical trials
The Role of Stress Neuromodulators in Decision Making Under Risk (Part II) (SID2)

The aim of the proposed project is to combine precise pharmacological manipulation of the noradrenergic system with behavioral modeling of memory processes, and fMRI methods to study the effect of a pharmacologically induced blockade of the noradrenergic system on memory processes. Behaviorally, the investigators will focus on the effect of …

Accepts healthy volunteers
  • 27 Apr, 2022
  • 1 location
The Influence of Polymeric Versus Oligomeric Enteral Feeding on Tolerance and Nutritional Status in Paediatric Intensive Care Pilot (Polygomerpilot)

Malnutrition is associated with negative impact on morbidity and mortality of critically ill patients. Therefore, in patients unable of peroral intake, the nutritional support is indicated. The preferred form of nutritional support is enteral, the more natural form, compared to parenteral. The enteral nutrition is cheaper and is associated with …

  • 12 May, 2022
  • 1 location
Ilomedin in Septic Shock With Persistent Microperfusion Defects (I-MICRO) (I-MICRO)

Septic shock remains a major cause of death in critically ill patients. Alterations in microcirculation have long been proposed as a key pathophysiological factor of organ dysfunction and death in septic shock patients. Persistence of mottling, prolonged skin recoloration time and cyanosis of the extremities are the easily and frequently …

  • 26 Feb, 2022
  • 1 location
Transcranial Electrostimulation and Obstructive Sleep Apnea Surgery

Postoperative pain after major surgery for obstructive sleep apnea (OSA), such as palatopharyngoplasty (PPP) and maxillomandibular advancement (MMA) is moderate-to-severe, and may persist for weeks. Control of this pain may be difficult, because OSA patients are very sensitive to traditional opioid pain medications, and their side effects. Poorly controlled pain …

  • 27 May, 2021
  • 1 location
Sacral Nerve Stimulation for Mild-to-Moderate or Refractory Rheumatoid Arthritis

This pilot study will assess the efficacy of sacral never stimulation (SNS) for the treatment of adult patients with active, mild-to-moderate rheumatoid arthritis or those with refractory disease. The study will enroll 60 subjects in a single center. All eligible subjects will be randomly divided into two groups at a …

Accepts healthy volunteers
  • 13 Mar, 2022
  • 1 location
Impact of an Assisted Fluid Management System on Microvascular Parameters

This study will compare a group of patients managed with a manual GDFT protocol (using the EV1000 monitoring device; Edwards Life sciences, Irvine, USA) to a group of patients managed using a novel real time clinical decision support system for goal directed fluid therapy (GDFT) guidance on microvascular parameters in …

  • 04 Jan, 2022
  • 1 location
Effects of MDMA-like Substances in Healthy Subjects

The serotonin (5-HT) and oxytocin releaser and so-called "empathogen" 3,4-methylenedioxymethamphetamine (MDMA) acutely produces positive feelings, empathy, and trust. MDMA is used recreationally (ecstasy), as research tool to study 5-HT and oxytocin function, and is investigated for MDMA-assisted psychotherapy. MDMA is metabolized in part (10%) to the psychoactive metabolite 3,4-methylenedioxyamphetamine (MDA) …

Accepts healthy volunteers
  • 05 Jan, 2022
  • 1 location
Tianeptine for Treatment Resistant Depression

The study will be conducted in parallel at two sites: the Clinic for Aging, Anxiety and Mood Disorders (CAAM) at Columbia University/New York State Psychiatric Institute (CU/NYSPI) and the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai (MSSM). The following procedures will be approved …

depressive disorder
  • 21 Apr, 2022
Improving Tissue Oxygenation in Breast Reconstruction Surgery

Breast reconstruction is an integral part of breast cancer care. There are two main types of breast reconstruction: alloplastic (using implants), and autologous (using patient's tissue). The latter creates a more natural breast mound, and avoids long-term concerns requiring surgical re-intervention associated with implant-based surgery. The deep inferior epigastric perforator …

  • 21 Apr, 2022
  • 2 locations

The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP 85 mmHg, delayed resumption of chronic antihypertensive medications, and a target ward systolic

  • 28 Aug, 2021
  • 3 locations