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Found 24 clinical trials
Multi-Institutional Pilot Study of Total Body Irradiation Using Intensity Modulated Radiation Therapy (IMRT) (VMAT or Tomotherapy) for Allogeneic HSCT With New Lung Radiation Dose Guidelines to Prevent Pul Toxicities

This trial studies how well radiation therapy techniques, volumetric modulated arc therapy (VMAT) and tomotherapy, work to reduce doses to the lung compared to standard total body irradiation methods to prevent pulmonary toxicities. Standard total body irradiation is limited in its ability to spare normal organs, with only the lung …

cyclophosphamide
acute leukemia
leukemia
etoposide
total body irradiation
  • 0 views
  • 25 Oct, 2022
  • 1 location
TMLI and Alemtuzumab for Treatment of Sickle Cell Disease

This phase I trial tests the safety and effectiveness of total marrow and lymphoid irradiation (TMLI) and alemtuzumab as a conditioning regimen in patients with sickle cell disease. Conditioning regimens are treatments used to prepare a patient for stem cell transplantation. A stem cell transplant is a procedure in which …

acute chest syndrome
Accepts healthy volunteers
hydroxyurea
osteonecrosis
cancer
  • 0 views
  • 04 Oct, 2022
  • 1 location
MSCs for Prevention of MI-induced HF

Results from recent clinical trials on bone marrow mononuclear cell (BM-MNC) transplantation show that this intervention can help reduce the incidence of heart failure (HF) after acute myocardial infarction (AMI). However, no study has evaluated the effect of the transplantation of mesenchymal stem cells (MSCs) on a clinical endpoint such …

aspirin
myocardial infarction
heart failure
aldosterone
rehabilitation program
  • 0 views
  • 23 Sep, 2021
  • 2 locations
Randomized Phase II Trial of Osimertinib With or Without Local Consolidation Therapy (LCT) for Patients With EGFR-Mutant Metastatic NSCLC (NORTHSTAR)

This phase II trial studies how well osimertinib, surgery, and radiation therapy work in treating patients with stage IIIB or IV non-small cell lung cancer with EGFR mutations. Osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high …

oophorectomy
MRI
ct scan
x-rays
measurable disease
  • 186 views
  • 16 Oct, 2022
  • 4 locations
Phase 2 Study of Imprime PGG and Pembrolizumab in Patients With HR+/HER2- Metastatic Breast Cancer (mBCA)

The primary objective of this Phase 2 Simon 2-Stage study is to determinate the Overall Response Rate (ORR) per RECIST v1.1 following treatment with Imprime PGG + pembrolizumab in patients with ER/PR+/ HER2(-) metastatic breast cancer who have progressed through prior hormone therapy with at least one CDK4/6 inhibitor, and …

estrogen receptor
tumor cells
progesterone
immunohistochemistry
hormone therapy
  • 0 views
  • 04 Oct, 2022
  • 7 locations
Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer

This phase III trial studies how well nivolumab and ipilimumab works with or without local consolidation therapy in treating patients with stage IV non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the …

oophorectomy
RET
nivolumab
metastasis
carcinoma
  • 53 views
  • 19 Jun, 2022
  • 5 locations
Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)

Background Electroconvulsive therapy (ECT) is used to treat people with severe depression. During ECT, the brain is given electric pulses that cause a seizure. Although it is effective, it can cause side effects, including memory loss. Researchers want to study a new way to give ECT called iLAST. Objective To …

electroconvulsive therapy
scid
depression
depressed mood
severe depression
  • 6 views
  • 23 Oct, 2022
  • 1 location
Cochlear Implanted Listening Effort and Hearing Attention (EffICAtt)

Cochlear implant users perceive mainly sound amplitude modulation cues. Processing of these amplitude modulations can be subject to interferences, so that the perception of a modulation in a target sound can be impaired by a superimposed sound if this sound contains a similar modulation. Such phenomenon, which is observed both …

audiogram
audiometry
Accepts healthy volunteers
cochlear implant
  • 0 views
  • 22 Mar, 2022
  • 1 location
Stimulant Effects on Disruptive Behavior

The goal of this study is to determine the effects of stimulant medication on disruptive behavior, function, preference and choice; however, it is primarily methodological and will add to current research by establishing an effective evaluation of the impact of stimulant medication on these behaviors. Three behavior assessments for children …

Accepts healthy volunteers
behavioral disorder
behavior disorders
impulsive behavior
hyperactivity
  • 10 views
  • 16 Feb, 2022
  • 1 location
Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes (XLPAD)

XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients. The study will create a registry that will include entry of procedural and clinical follow-up information into an online data collection software, REDCAP.Data available since Jan 1 2005 will …

revascularisation
vascular disease
endovascular intervention
arteriopathy
stroke
  • 114 views
  • 25 May, 2022
  • 16 locations