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Found 83 clinical trials
A Study of HLX10 in Combination With Carboplatin Plus (+) Pemetrexed With or Without HLX04 Compared With Carboplatin+Pemetrexed in 1L Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

line Stage IIIB/IIIC or IV non-squamous NSCLC. Participants will be randomized in a 1:1:1 ratio to Arm A (HLX10+HLX04+Carboplatin+Pemetrexed), Arm B (HLX10+Carboplatin+Pemetrexed), or Arm C

administration intravenous
cancer
pemetrexed
lung cancer
EGFR
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body. Participants who are assigned to the standard treatment and discontinue due to progressive disease have

lung carcinoma
kidney function test
carboplatin
pemetrexed
pembrolizumab
  • 16 views
  • 12 May, 2021
  • 316 locations
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

induction with pembrolizumab, pemetrexed and carboplatin followed by pembrolizumab and pemetrexed maintenance in treating patients with stage IV non-squamous non-small cell lung cancer. Immunotherapy with

tyrosine
leptomeningeal disease
monoclonal antibodies
chronic hepatitis b
hepatitis c virus
  • 206 views
  • 09 May, 2021
  • 819 locations
Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer

This randomized phase II/III trial studies how well giving maintenance chemotherapy with or without local consolidation therapy works in treating patients with stage IV non-small cell lung cancer. Drugs used in maintenance chemotherapy, such as docetaxel, pemetrexed disodium, erlotinib hydrochloride, and gemcitabine work in different ways to stop the growth …

cancer
pemetrexed
stage iv non-small cell lung cancer
systemic chemotherapy
lung cancer
  • 238 views
  • 07 Mar, 2021
  • 189 locations
A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors

This trial will study ladiratuzumab vedotin (LV) to find out if it works to treat different types of solid tumors. It will also find out what side effects may occur. A side effect is anything the drug does besides treating cancer.

BRAF
platinum-based chemotherapy
cancer
extensive disease
human epidermal growth factor
  • 12 views
  • 07 May, 2021
  • 56 locations
Study of Anlotinib in Non-squamous NSCLC Patients Who Failed First-Line ALTER-L020

Anlotinib is a multi-target receptor tyrosine kinase inhibitor in domestic research and development. It can inhibit the angiogenesis related kinase, such as VEGFR, FGFR, PDGFR, and tumor celltebiz related kinase -c-Kit kinase. In the phase III study, Patients who failed at least two kinds of systemic chemotherapy (third line or …

  • 0 views
  • 24 Jan, 2021
  • 1 location
Bevacizumab Combined With Fractionated Stereotactic Radiotherapy for 1 to 10 Brain Metastases From Non-squamous NSCLC

non-squamous non-small cell lung cancer by assessing the treatment response, perilesional edema, neurological symptoms and quality of life.

contrast-enhanced mri
tyrosine
bevacizumab
fractionated stereotactic radiotherapy
lung cancer
  • 1 views
  • 24 Jan, 2021
  • 1 location
  • 3 views
  • 24 Jan, 2021
  • 2 locations
Predicting Response to Neoadjuvant ATEZOLIZUMAB Plus Carboplatin/Nab Paclitaxel in Resectable Non-squamous NSCLC

Exploratory study evaluating the potential of immune signature profiling for predicting response in patients with resectable Stage II, IIIA and select IIIB (T3N2 only) non-squamous Non-Small

  • 0 views
  • 07 May, 2021
  • 1 location
Rucaparib and Pembrolizumab for Maintenance Therapy in Stage IV Non-Squamous Non-Small Cell Lung Cancer

patients with stage IV non-squamous non-small cell lung cancer (NSCLC) without progressive disease (PD), as confirmed on CT scans, after induction therapy with carboplatin/pemetrexed/pembrolizumab (CPP

cancer
pemetrexed
growth factor
anaplastic lymphoma
pembrolizumab
  • 8 views
  • 25 Jan, 2021
  • 3 locations