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Found 560 clinical trials
Investigation of the Timely-coordinated Therapy of Patients With Metastatic Cancer by Radiotherapy Together With Immune Checkpoint Inhibition

checkpoint inhibition (ICI) also for advanced metastatic patients. Especially the ICI with pembrolizumab and nivolumab have an increasing number of first line treatment approvals. However, in particular

ipilimumab
nivolumab
pd-l1
cancer
metastasis
  • 11 views
  • 24 Jan, 2021
  • 1 location
Spanish Real-World Evidence Cabozantinib

ccRCC. The frontline treatment paradigm for ccRCC has evolved, particularly for intermediate-/poor-risk patients, with the recent addition of cabozantinib and nivolumab/ipilimumab (immunotherapy

kidney cancer
tyrosine
ipilimumab
cancer
carcinoma
  • 0 views
  • 25 Jan, 2021
  • 29 locations
Immune Monitoring in Metastatic Melanoma

antigen 4 (CTLA-4); Pembrolizumab and nivolumab cause immune stimulation by binding the Programmed Death Receptor (PD1). However, the impact of the therapy on the immune system as a whole is

  • 0 views
  • 23 Jan, 2021
  • 1 location
Evaluation of the Clinical/Biological Characteristics Efficacy and Safety of Patients With Malignant Pleural Mesothelioma Treated by Immunotherapy

The objective of this multicentre descriptive analysis is to describe the clinical and biological characteristics of patients who have received Programmed cell death 1 (anti-PD1) / (PDL1) Programmed death-ligand 1 (PDL1) immunotherapy outside of a clinical trial in terms of efficacy and safety.

  • 0 views
  • 07 Mar, 2021
  • 5 locations
LIFE - Lung Cancer Immunotherapy Frailty Effect

The LIFE study (Lung cancer, Immunotherapy, Frailty, Effect) is investigating the unselected 'real life' non-small cell lung cancer (NSCLC) population treated with immune checkpoint inhibition.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Memory Phenotype in Oral Cancer

The purpose of this research study is collect tissue and blood samples from patients who are having surgery and use those samples in lab studies to see if there are any markers in blood and tissue that can help predict how cancer will react to different treatment. Participants in this …

cancer
metastasis
squamous cell carcinoma
  • 0 views
  • 27 Jan, 2021
  • 1 location
Breathomics as Predictive Biomarker for Checkpoint Inhibitor Response

Immunotherapy with agents stimulating the immune system to act against cancer are now a new standard of care in various cancers as lung cancer and melanoma, but also bladder cancer, kidney cancer and head & neck cancer. However, even though a subset of patients derives long-term benefit from these agents, …

ipilimumab
docetaxel
cancer chemotherapy
bladder cancer
solid tumors
  • 1 views
  • 24 Jan, 2021
Immune Checkpoints in Intraabdominal Ascites Fluid

Colorectal cancers are the third most common type of cancer in the world. Peritoneal carcinomatosis and intraabdominal acid development occur in advanced stages of colorectal cancers. It is known that the immune system plays an important role in tumor development or tumor eradication. Among the mechanisms of escape from the …

  • 0 views
  • 31 Jan, 2021
  • 1 location
The Efficacy of Immunodetection Point Inhibitors for Advanced Esophageal Cancer

Esophageal cancer is one of the most common malignancies of the digestive system. Esophageal squamous cell carcinoma is the main type of esophageal cancer, accounting for more than 90% of esophageal cancer in China. The 5-year survival rate is about 15%~25%. Many patients with esophageal cancer are initially diagnosed as …

  • 0 views
  • 23 Jan, 2021
  • 1 location
TDM for Optimized Outcome in Patients With mRCC.

The purpose of this observational study is to assess the role of plasma concentration monitoring of treatment drugs for patients with metastatic renal cell carcinoma (mRCC) in terms of efficacy and side effects. Furthermore, the investigators intend to evaluate the role of anti-drug antibodies, amount of bound drug to T …

  • 0 views
  • 27 Jan, 2021
  • 3 locations