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Found 24 clinical trials
The BEET-BP Trial - Investigating the Effect of Dietary Nitrates on Hypertension in Pregnancy

This is a randomised placebo controlled trial investigating the effects of dietary nitrate supplementation on hypertension in pregnancy

fetal growth retardation
hypertension
stroke
prenatal
acute kidney injury
  • 0 views
  • 27 Jan, 2021
  • 1 location
Coreg CR Blood Vessel Stiffness and Blood Vessel Function

We are comparing the blood pressure-lowering effects of two marketed medications, Coreg CR and Toprol XL. Although both drugs reduce blood pressure by blocking the action of noradrenaline on beta-receptors in the blood vessels, Coreg CR also blocks alpha-receptors, which may provide added blood pressure-lowering. In addition, Coreg CR may …

antihypertensive drugs
glycosylated hemoglobin
type 2 diabetes mellitus
metoprolol
antidiabetic agents
  • 41 views
  • 07 Nov, 2020
  • 1 location
Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters

The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG) dose to be used …

urinary symptoms
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction

This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in healthy adult normal volunteers compared to volunteers with PH-HFpEF in the breakdown of oral nitrate.

hypertension
right heart catheterization
heart failure
ejection fraction
heart disease
  • 20 views
  • 31 Jan, 2021
  • 1 location
Effect of Beetroot Juice on Coronary Blood Flow and Walking Performance in PAD

In this study the investigators will test the hypothesis that short-term consumption of inorganic nitrate (supplied in concentrated beetroot juice) enhances coronary blood flow responses, large artery hemodynamics, and leg oxygenation/exercise tolerance in patients with peripheral arterial disease (PAD). Understanding and improving blood flow regulation in the heart and skeletal …

arteriopathy
vascular disease
leg pain
  • 176 views
  • 15 Feb, 2021
  • 1 location
Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage

This study aims to determine whether dietary inorganic nitrate (in beetroot juice) is able to reduce overall thickening of the heart (left ventricular hypertrophy or LVH) and stiffness of the arteries when given to patients with persistently raised blood pressure (hypertension). Half the patients will receive the beetroot juice containing …

hypertension
raised blood pressure
antihypertensive drugs
left ventricular hypertrophy
stiffness
  • 0 views
  • 25 Jan, 2021
  • 1 location
Dietary Nitrate Vascular Function and Inflammation

The risk for cardiovascular diseases (CVD) increases with advancing age. Developing effective lifestyle-based strategies to promote, preserve or restore cardiovascular health with aging is a high priority. The overall aim of this clinical research is to investigate the innovative concept that an increased intake of dietary nitrate (through beetroot juice) …

  • 0 views
  • 14 Feb, 2021
  • 2 locations
Inorganic NItrate and EXercise Performance in Heart Failure (iNIX-HF): Dose Response

The purpose of this study is to do the work that is necessary and sufficient for setting up an appropriate multi-center, randomized clinical trial (RCT) of a new therapy for heart failure: inorganic nitrate. The investigators will first determine the effects and palatability of ~12.8mmol KNO3 (an oral pill) as …

aerobic exercise
medical therapy
angiotensin converting enzyme
angiotensin ii receptor antagonists
angiotensin
  • 32 views
  • 19 Feb, 2021
  • 1 location
Impact of Estrogen + Estradiol Receptor Alpha Modulator Therapy on Oxidative Stress in Post-menopausal Women With and Without Sleep Apnea

One of the most likely mechanisms explaining the sleep apnea (SA)-induced increase in metabolic syndrome is the oxidative stress (OS) induced by intermittent hypoxia (IH). There are clear-cut signs of OS in postmenopausal women that may be further enhanced by SA. In rats exposed to IH, an estradiol receptor alpha …

hypoxia
insomnia
  • 18 views
  • 23 Jan, 2021
  • 1 location
Determining Airway pH by Compartmental Exhaled Nitric Oxide Levels During Alkaline Buffer Challenge

Airway pH imbalances cause numerous adverse physiological changes within the airways, including hyperreactivity, cough, bronchoconstriction, ciliopathy, decreased response to bronchodilators, bacterial growth, nitrosative/oxidative stress, neutrophilic/eosinophilic inflammation, and cell death. Airway pH is known to be low (acidic) in chronic and acute pulmonary diseases. The gold standard approach to measuring airway …

  • 0 views
  • 13 Feb, 2021
  • 1 location