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Found 22 clinical trials
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers

The investigators propose a Phase II study, prospective and placebo controlled, of a topical cream containing sodium nitrite compared to the current standard of care. Sodium nitrite is a local

nitric oxide
thalassemia
leg ulcer
nitrite
  • 23 views
  • 27 Jan, 2021
  • 2 locations
Oral Nitrite in Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction

The main objective of this study is to determine the clinical efficacy of oral inorganic nitrite verses placebo and the therapeutic response with regards to exercise tolerance in patients with

ejection fraction
heart failure with preserved ejection fraction
  • 1 views
  • 26 Jan, 2021
  • 1 location
Nitrite-boosting Therapy for Improving Physiological Function in Patients With Chronic Kidney Disease

Nitric oxide (NO) is an essential molecule in the body that is decreased in patients with chronic kidney disease (CKD), leading to reductions in vascular, movement ("motor") and cognitive functions. This study will determine if daily oral supplementation (3 months) with a supplement that increases NO in the body, i.e., …

renal function study
nephropathy
  • 7 views
  • 23 Jan, 2021
  • 1 location
Nutritional Supplementation and Insulin Sensitivity

with a specific combination of other nutritional components (i.e. nitrate and nitrite), which are already part of the regular diet and support alternative pathways to improve NO- mediated vascular

  • 0 views
  • 26 Jan, 2021
  • 1 location
Inorganic Nitrite to Amplify the Benefits and Tolerability of Exercise Training in Heart Failure With Preserved Ejection Fraction (HFpEF) (INABLE-Training)

Participants with heart failure with preserved ejection fraction will undergo 12 weeks of cardiac rehabilitation for exercise training (ET) and be randomized to either oral sodium nitrite

dyspnea
rehabilitation program
hypertension
edema
cardiac rehabilitation
  • 0 views
  • 24 Jan, 2021
  • 1 location
Dietary Nitrate and Erectile Dysfunction

An expanding number of studies suggest a therapeutic role for nitrate and nitrite, most notably in treatment and prevention of cardiovascular disease including ischemia-reperfusion injury and

  • 0 views
  • 27 Jan, 2021
  • 1 location
The Effect of Propolis Mouthwash Compared to Chlorhexidine Mouthwash on Oral and Cardiovascular Health

The oral microbiome has recently emerged as a key contributor in nitric oxide (NO) homeostasis and vascular control by increasing nitrite bioavailability. Antibacterial mouthwash containing

  • 0 views
  • 26 Jan, 2021
  • 1 location
The Causal Relation of Nasal Nitric Oxide Levels to the Severity of Chronic Rhinosinusitis and Its Inflammatory Phenotype

the relation of chronic rhino sinusitis (CRS) severity and inflammatory status to nNO, maxillary sinus NO, nitrite, nitrate and cone beam computed tomography (CBCT). Three groups (22 patients

ct scan
asthma
rhinosinusitis
nitrite
  • 0 views
  • 24 Jan, 2021
  • 1 location
Influence of Freeze Dried Strawberry Consumption on Gut Microbiota and Cardiovascular Health.

the influence of the FDSP on circulating levels of nitrate and nitrite and trimethylamine oxide (TMAO) as markers of vascular health that are influenced by both dietary intake and the oral and gut

  • 108 views
  • 24 Jan, 2021
  • 1 location
Heat Therapy in Older Hypertensive Women

control, vasodilator function, and interstitial metabolites (i.e. nitrate and nitrite) indicative of basal nitric oxide bioavailability in all patients enrolled in Aim 1 before and after 8 weeks of heat

  • 59 views
  • 25 Jan, 2021
  • 1 location