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Found 193 clinical trials
Featured trial
Role of Genetic Factors in the Pathogenesis of Lung Disease

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible for processes …

pulmonary fibrosis
pulmonary disease
  • 23 Nov, 2020
  • 1 location
Featured trial
Ph 2a study of CY6463 in participants with Alzheimer’s disease and vascular pathology

This study is being conducted to evaluate an oral investigational drug called CY6463 in individuals 60 years of age and older who have Alzheimer’s disease (AD) and common cardiovascular risk factors such as high blood pressure, diabetes, high cholesterol, and/or elevated body mass. The main goals of this study are to …

mini-mental state examination
alzheimer's disease
mental state examination
  • 30 Mar, 2022
  • 4 locations
Nitric Oxide Nasal Spray (NONS) as Prevention for Treatment of Individuals at Risk of Exposure to COVID-19 Infection

A multicenter, randomized, double-blinded, placebo-controlled, phase 3 clinical efficacy study evaluating nitric oxide nasal spray (NONS) as prevention for treatment of individuals at risk of

Accepts healthy volunteers
  • 12 May, 2022
  • 5 locations
A Study to Evaluate the Efficacy and Safety of Dupilumab in Participants With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED)

total immunoglobulin E (IgE) and Aspergillus-specific IgE concentrations To evaluate the effects of dupilumab on Fractional exhaled Nitric Oxide (FeNO) levels To evaluate safety and

  • 06 May, 2022
  • 60 locations
Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH) (A DUE)

Combination therapy in pulmonary arterial hypertension (PAH) has been the subject of active investigation for more than a decade, with the benefit of targeting different pathways known to be involved in the pathogenesis of the disease. Adherence to prescribed therapy has an impact on clinical outcomes. Reducing the pill/tablet count …

  • 12 May, 2022
  • 135 locations
Combined Air-plasma Flow and Nitric Oxide Therapy in Cardiac Surgery

complications is beyond doubt. In this study, it is supposed to examine and evaluate the effectiveness of the combined effects of air-plasma flow and nitric oxide in the treatment of postoperative infectious

  • 21 Mar, 2022
  • 1 location
Comparison of Vasodilator Response of Inhaled Epoprostenol and Inhaled Nitric Oxide

The overarching goal of this study is to examine the acute vasoreactive response to both inhaled nitric oxide and inhaled epoprostenol across both traditionally and non-traditionally

nitric oxide
right heart catheterization
  • 24 Mar, 2022
  • 1 location
  • 04 Aug, 2021
  • 1 location
Exercise Fatiguability in Older Adults: The Protective Effects of Dietary Nitrate Supplementation

Vascular and skeletal muscle function decline with age and are associated with decreased nitric oxide (NO) bioavailability. Dietary nitrate supplementation in the form of beet root juice

Accepts healthy volunteers
  • 27 Apr, 2022
  • 1 location
Inorganic Nitrate: Sex Differences in Muscle Contractile Function and Efficiency

Dietary inorganic nitrate, in the form of beet root juice, is a nutritional intervention, considered to be an exercise enhancer due to its capacity to increase Nitric Oxide (NO) bioavailability

Accepts healthy volunteers
  • 14 Mar, 2022
  • 1 location