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Found 34 clinical trials
Tyrosine Kinase Inhibitors and Low Intensity Chemotherapy in Ph+ ALL

combining nilotinib in combination with low-intensity chemotherapy is currently initiated within the EWALL centers. 3. The EWALL-PH-01 trial is now closed after the recruitment of 71 patients. The

dasatinib
dexamethasone
vincristine
imatinib
nilotinib
  • 8 views
  • 22 Jan, 2021
  • 3 locations
The Hong Kong CML Registry

Chronic myeloid leukaemia (CML) is a malignant disorder of the haematopoietic system. It is characterized by the chromosomal translocation between chromosomes 9 and 22, resulting in the formation of the Philadelphia chromosome which contains the BCRABL1 fusion gene. The projected prevalence of CML is rising steadily, due to the significantly …

tyrosine
leukemia
philadelphia chromosome
  • 24 views
  • 12 Feb, 2022
  • 1 location
Observational Study of Conception/Pregnancy in Adult Patients With CML Treated With Tyrosine Kinase Inhibitors (CML1012)

The objective of this study is to acquire more information about what we are doing during pregnancy in CML patients, in order to possibly establish in the future a consensus on the management of patients receiving TKIs who wants to father a child or become/are pregnant.

tyrosine
  • 13 views
  • 25 Mar, 2022
  • 34 locations
Is There an Association Between Innate CD8+ T Cells and the Evolution of Tyrosine Kinase Inhibitor Resistance Mutations in Phi+ Hematological Malignancies.

The aim of this project is to test whether low levels of BcrAbl1, despite the presence of resistance mutations, are related to high levels of innate CD8+ T cells, in the hypothesis that these cells have an anti-tumor role. This research aims to investigate: An association between the rate of …

tyrosine
flow cytometry
chronic myeloid leukemia
myeloid leukemia
kinase inhibitor
  • 0 views
  • 30 Jul, 2021
  • 1 location