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Found 4 clinical trials
Testing the Use of Fulvestrant and Binimetinib Targeted Treatment for NF1 Mutation in Hormone Receptor-Positive Metastatic Breast Cancer, A ComboMATCH Treatment Trial

This ComboMATCH phase II trial compares the usual treatment alone (fulvestrant) to using binimetinib plus the usual treatment in patients with hormone receptor positive breast cancer that has spread to other places in the body (metastatic) and has an NF1 genetic change. Fulvestrant is a hormonal therapy that binds to …

  • 11 Apr, 2023
  • 2 locations
Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy (PLGG - MEKTRIC)

will focus on a specific group of PLGGs without any congenital NF1 mutation and with a wild-type BRAF gene in the tumor. In this subgroup, for instance, the PFS is not increasing anymore above 50% at 3

  • 04 Oct, 2022
  • 1 location
Molecularly Targeted Umbrella Study in Luminal Advanced Breast Cancer

This study is a prospective, single-center, open-label, umbrella-shaped phase II clinical study for patients with HR+/HER2- endocrine-resistant advanced breast cancer.

locally advanced breast cancer
advanced breast cancer
  • 04 Oct, 2022
  • 1 location
Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight

Simons Searchlight collects medical, behavioral, learning, and developmental information from people who have gene changes that are linked to autism and other neurodevelopmental disorders. The goal of this study is to improve the clinical care and treatment for these people. Simons Searchlight partners with families to collect data and distribute …

genetic testing
  • 03 Oct, 2021
  • 3 locations