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Found 59 clinical trials
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Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

Background Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

aplastic anemia
hematologic disorder
blood disorder
immunosuppression
horse anti-thymocyte globulin
  • 114 views
  • 18 Jul, 2021
  • 1 location
None
A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients

This is a phase 1, open-label, single centre study of investigational drug selinexor in participants with soft tissue sarcomas that cannot be treated with standard therapies. Selinexor has been given to 3111 participants with cancer to date including 142 sarcoma patients. Early findings have shown that selinexor is effective in …

  • 0 views
  • 04 Apr, 2021
  • 1 location
None
To Study Efficacy of Albumin in Cirrhosis With Spontaneous Bacterial Peritonitis at Low Risk for AKI Development

The role of Albumin in prevention and Treatment of Acute Kidney Injury (AKI) in patients with Spontaneous Bacterial Peritonitis (SBP) who are at high risk of AKI development has been clearly defined , which decreases the morbidity and mortality. But the role of Albumin in patient with SBP who are …

renal injury
acute renal failure
cirrhosis
spontaneous bacterial peritonitis
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
COVID-19 Pneumonitis Low Dose Lung Radiotherapy (COLOR-19)

Low-dose radiotherapy treatment delivered to both lungs in patients with immune-related pneumonia following COVID-19 infection is backed up by biological and clinical bases that justify its use as a possible therapeutic option in these patients. This is a preliminary exploratory study (non-pharmacological interventional) to evaluate the feasibility and tolerability of …

covid-19
SARS
pneumonia
chest ct
chest x-ray
  • 0 views
  • 25 Jan, 2021
  • 1 location
None
Reduced Intensity BMT for Immune Dysregulatory and Bone Marrow Failure Syndromes Using Post-Transplant Cyclophosphamide

This is a Phase II prospective trial to assess the rates of donor engraftment using reduced intensity conditioning (RIC) hematopoietic stem cell transplant (HSCT) and post-transplant cyclophosphamide (PTCy) for patients with primary immune deficiencies (PID), immune dysregulatory syndromes (IDS), and inherited bone marrow failure syndromes (IBMFS).

stem cell transplantation
hla-a
immune globulin
immunodeficiency
immunoglobulin e
  • 0 views
  • 24 Sep, 2021
  • 1 location
None
a Phase II Study in Primary Central Nervous System Lymphoma

In this study we will test the hypothesis that concurrent chemoradiation (CCRT) with temozolomide after induction chemotherapy by conventional high-dose methotrexate (HD-MTX) plus dexamethasone may be an effective and well tolerated treatment for immunocompetent patients with PCSNL. Corticosteroid can effectively reduce brain edema and corticosteroid alone has resulted in complete …

methotrexate
treatment regimen
nervous
whole-brain radiotherapy
methylprednisolone
  • 1 views
  • 07 Nov, 2020
  • 4 locations
None
Safety and Tolerability of Intravenous Fish Oil Lipid Emulsion in Children Undergoing Hematopoietic Cell Transplantation

Children undergoing hematopoietic cell transplantation (HCT) for cancer or blood disorders frequently develop gastrointestinal, metabolic and infectious complications related to preparative high-dose chemotherapy and/or radiation-related toxicity. Parenteral nutrition (PN) with lipid emulsion is commonly required while gastrointestinal complications preclude adequate oral or enteral intake. PN and lipids may increase the …

hematologic disorder
nutritional care
hla-a
busulfan
fish oil
  • 3 views
  • 14 May, 2021
  • 1 location
None
Cyclosporine For The Treatment Of COVID-19(+)

Phase IIa clinical trial in which 75 non-ICU hospital inpatients will be randomized 2:1 to 7 days of an oral formulation of cyclosporine, Neoral (2.5mg/kg PO BID) + standard of care (SOC) or no Neoral + SOC. The primary endpoint is disease severity based on the World Health Organization (WHO) …

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
EfiKroniK Research Program: Physical Exercise for People With Chronic Pathologies

Clinical objectives: estimate the common effect of the EfiKroniK physical exercise program for people with a set of Chronic diseases (solid cancers, hematological, schizophrenia and COPD), expressed in terms of functional capacity, quality of life and others results, regarding the standardized intervention of healthy habits 'Prescribe Healthy Living 'PVS. Implementation …

corticosteroids
cancer
absolute neutrophil count
antibiotics
psychosis
  • 0 views
  • 25 Jan, 2021
  • 1 location
None
Microbiology and Clinical Outcome of Pneumonia

1. BACKGROUND Pneumonia occurring outside of the hospital setting is regarded as community acquired pneumonia. However, pneumonia occurring in non-hospital long-term care facilities constituted a distinct type of pneumonia from CAP. Kollef et al has justified health care associated pneumonia (HCAP) as a new category of pneumonia [1]. The HCAP …

methicillin
antibiotic therapy
hcap
community acquired pneumonia
antibiotics
  • 1 views
  • 07 Nov, 2020
  • 1 location