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Found 55 clinical trials
Collection of Granulocytes by Apheresis of Healthy Donors Stimulated With Filgrastim (G-CSF) and Dexamethasone

Background White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells. Transfusions of these cells can help improve the body's ability to fight infection. However, most of the cells are located in the …

Accepts healthy volunteers
  • 41 views
  • 28 Oct, 2022
  • 1 location
Early Termination of Empirical Antibiotics in Febrile Neutropenia in Children With Cancer

The study is a nationwide, multicenter, open label, randomized controlled trial. A target population of 220 children in treatment for cancer with neutropenic fever and a neutrophil count

  • 0 views
  • 26 Jan, 2021
  • 3 locations
Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Stem Cell Transplantation

subject's choice. The intervention will begin approximately 10 days prior to stem cell infusion and will continue until the first day of neutrophil engraftment (first day absolute neutrophil count >500

follicular lymphoma
lymphoma
cell transplantation
neutrophil count
t-cell lymphoma
  • 0 views
  • 29 Apr, 2022
  • 1 location
Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

engraftment, graft versus host disease, neutrophil count, and incidence and severity of mucositis (inflammation of the mouth or gut) and infection. This study has two cohorts. The first cohort is subjects

myeloid leukemia
fludarabine
melphalan
ejection fraction
cell transplantation
  • 42 views
  • 26 May, 2022
  • 1 location
Sitagliptin for Prevention of aGVHD After Alternative Donor Transplatation

absolute neutrophil count and platelets. To evaluate the incidence of CMV, EBV and other infections occurring during the 100 days post-transplant. To study non-relapse mortality (NRM) at

  • 0 views
  • 24 Mar, 2022
  • 1 location
EXTEND EXpanding Treatment for Existing Neurological Disease

The primary goal of the Phase II EXTEND trial is to investigate the effects of open-label hydroxyurea treatment, escalated to maximum tolerated dose, for children with Sickle Cell Anemia and either conditional (170 - 199 cm/sec) or abnormal (≥200 cm/sec) Transcranial Doppler velocities. The primary endpoint will be measured after …

thalassemia
hydroxyurea
stroke
anemia
transcranial doppler ultrasonography
  • 19 views
  • 24 Apr, 2022
  • 1 location
211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

This phase I/II trial studies the side effects and best dose of a radioactive agent linked to an antibody (211At-BC8-B10) followed by donor stem cell transplant in treating patients with high-risk acute leukemia or myelodysplastic syndrome that has come back (recurrent) or isn't responding to treatment (refractory). 211At-BC8-B10 is a …

total body irradiation
remission
stem cell transplantation
mycophenolate mofetil
hla-a
  • 0 views
  • 16 May, 2022
  • 1 location
Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia

RATIONALE: Giving chemotherapy, such as busulfan, fludarabine, and melphalan, before a donor umbilical cord blood stem cell transplant helps stop the growth of abnormal or cancer cells and prepares the patient's bone marrow for the stem cells. When the healthy stem cells from a donor are infused into the patient …

melphalan
minimal residual disease
stem cell transplantation
mycophenolate mofetil
bone marrow procedure
  • 37 views
  • 22 Mar, 2022
  • 1 location
A Phase I Study of Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-Selected CD34+ Cells

This phase I/II trial studies the side effects and best dose of gene therapy in treating patients with human immunodeficiency virus (HIV)-related lymphoma that did not respond to therapy or came back after an original response receiving stem cell transplant. In gene therapy, small stretches of deoxyribonucleic acid (DNA) called …

remission
enzyme-linked immunosorbent assay
melphalan
direct bilirubin
follicular lymphoma
  • 72 views
  • 21 Oct, 2022
  • 4 locations
Clinical Trial of a Novel Dose Adjustment Algorithm for Preventing Cytopenia-Related Delays During FOLFOX Chemotherapy

The study is testing an intervention of an investigator-developed chemotherapy dose adjustment algorithm. The primary objective of this study is to evaluate the effectiveness of the chemotherapy dose adjustment algorithm for reducing unplanned delays in patients receiving FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin)-type chemotherapy, while maintaining acceptable chemotherapy dose-intensity.

cetuximab
adenocarcinoma
leucovorin
panitumumab
trastuzumab
  • 0 views
  • 06 Nov, 2021
  • 1 location