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Found 12 clinical trials
Study of the Effect of Fostamatinib Upon Cutaneous Inflammation in the Setting of Hidradenitis Suppurativa

A 16 week exploratory, Proof of Concept study to evaluate the effect of Fostamatinib (12 weeks of treatment) upon cutaneous inflammation in Hidradenitis Suppurativa.

  • 27 Apr, 2022
  • 1 location
Woodsmoke Particulate + Prednisone (Smokisone)

Deployment of military personnel has been associated with increased respiratory illness likely due, in part, to inhalation of unusual particulate matter (PM), such as from burn pits. Inflammation is a key initial response to inhaled particulates. The researchers have developed a protocol using inhaled wood smoke particles (WSP) as a …

Accepts healthy volunteers
  • 08 Aug, 2022
  • 1 location
A Phase 1b/2 Study of Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

neutrophil elastase in the body. Researchers believe the new drug alvelestat (MPH966) may help. Objectives To test the safety of alvelestat (MPH966) and see what dose

  • 21 Sep, 2022
  • 1 location
Treatment of ARDS With Sivelestat Sodium (TOAWSS)

Neutrophil elastase (NE) released by neutrophils play an important role in inflammatory cascade and lung tissue injury of ARDS.Inhibition of NE is expected to prevent the pathophysiological

absolute neutrophil count
acute respiratory distress
  • 29 Apr, 2022
  • 1 location
Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD (InnovAATe)

Alpha-antitrypsin (AAT) is a member of the serpin family of proteinase inhibitors and is to a large extent responsible for restricting proteinases, notably neutrophil elastase, and proteinase 3

chronic obstructive pulmonary disease
alpha1-proteinase inhibitor (human)
protease inhibitor
forced expiratory volume
blood test
  • 21 Feb, 2022
  • 1 location
The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping

This study will be done to investigate perioperative lidocaine infusion on neutrophil extracellular trapping in the patients undergoing the robot-assisted prostatectomy.

  • 10 Oct, 2021
  • 1 location
A First in Class Disease Modifying Therapy to Treat Alpha-1 Antitrypsin Deficiency a Genetically Linked Orphan Disease (ATALANTa)

This is a Phase 2, multicenter, double-blind, randomized (1:1), placebo-controlled, 12-week, proof-of-concept study to evaluate the safety and tolerability as well as the mechanistic effect of oral administration of alvelestat (MPH966) in subjects with confirmed AATD defined as PiZZ, PiSZ, Pi*null, or another rare phenotype/genotype known to be associated with …

chronic obstructive pulmonary disease
alpha1-proteinase inhibitor (human)
  • 22 Sep, 2022
  • 10 locations
Baby Lung: an Observational Study

be analysed for levels of surfactant proteins in particular SP-D and inflammatory and immunological markers [cell counts of neutrophils, macrophages, MMPs, neutrophil elastase, IL-8, IL-6, IL 11 and

  • 18 Dec, 2021
  • 1 location
Breath Condensate Study in Patients With Cystic Fibrosis.

There is an urgent need for a noninvasive method to diagnose bronchial infections and exacerbations in patients with Cystic Fibrosis (CF). The current method to diagnosed infections involves either collecting a sputum sample or obtaining a bronchoalveolar lavage (BAL). However, some patients cannot produce sputum. At the same time the …

Accepts healthy volunteers
  • 24 Jul, 2022
  • 1 location
Pancreatic Injury and Corresponding Management Outcome (PICO)

Pancreatic injury is a relatively rare and result in significant morbidity and mortality. Estimates for the incidence of pancreatic injury range from 0.2-12% of abdominal traumas. Many factors, such as patient stability, the acuity of concomitant life-threatening injuries, and the need for damage control procedures must therefore be balanced when …

  • 25 Mar, 2022
  • 1 location