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Found 121 clinical trials
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Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease

Dopamine neurons made from stem cells are injected into the brain under general anesthesia. Subjects then take medicines to partially suppress their immune system (aimed to prevent the body from rejecting the cells) for 1 year.All subjects receive the treatment (i.e. there is no placebo group in this study).  Safety, …

dyskinesia
dopamine
  • 12 views
  • 13 Sep, 2021
  • 2 locations
IEIK13 For Neurosurgery

The objective of this clinical investigation is to determine the performance and safety profile of NU-MAX when used as a topical hemostat for oozing bleedings encountered during intracranial procedures, in which control of bleeding by conventional hemostatic techniques is either ineffective or impractical.

  • 0 views
  • 17 Sep, 2021
  • 1 location
MusiC to Prevent deliriUm During neuroSurgerY

Rationale: Delirium is a common and severe complication after neurosurgical procedures. Music before, during and after surgical procedures has proven its effectiveness in reducing pain, anxiety, stress and opioid medication in surgical patients. These symptoms belong to the main eliciting factors for developing delirium. Effective preventive therapy for delirium is …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Microdialysis permits sampling of molecules from the extracellular fluid, and has been utilized for studies of pharmacokinetics, and recovery of biomarkers. Gliomas remain incurable--in part due to limited access to human tumor biology in available preclinical models. This study utilizes a variable rate pump (M dialysis 107) and a high …

  • 0 views
  • 02 Aug, 2021
  • 1 location
Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial

Pseudotumor cerebri, also called idiopathic intracranial hypertension (IIH), is characterized by elevated intracranial pressure, headache, and if severe, vision loss. IIH is difficult to treat. Medical management may not adequately resolve the symptoms, and surgical management (primarily through cerebrospinal fluid [CSF] shunting) has a high failure rate. Recently, a relationship …

  • 0 views
  • 25 Jan, 2021
  • 1 location
Superficial Cervical Plexus Block for Postoperative Analgesia

The incidence of postoperative pain after craniotomy is high. Severe postoperative pain can lead to a series of complications that are detrimental to the recovery of craniotomy patients. Compound local scalp nerve block is a good choice for analgesia after craniotomy. However, the scalp nerve block commonly cannot cover the …

  • 0 views
  • 19 Sep, 2021
  • 1 location
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)

The aim of this trial is to test a new potential treatment, skullremodeling surgery (SR-surgery) combined with tumor treating fields (TTFields), for patients with first recurrence of malignant brain tumor (first recurrence of glioblastoma). Glioblastoma is one of the most malignant cancers. TTFields is a new treatment for brain cancer …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Deep braIn Stimulation for Tremor TractographIC Versus Traditional

at screening, baseline/neurosurgery, six and twelve months after neurosurgery.

movement disorder
neurosurgery
brain stimulation
  • 0 views
  • 04 Aug, 2021
  • 1 location
The Paediatric EVICEL Neuro Study

The purpose of this study is to evaluate the safety and efficacy of EVICEL when used for suture-line sealing in dura-mater closure in elective or urgent paediatric cranial neurosurgery to

  • 81 views
  • 19 Sep, 2021
  • 7 locations
Effects of Intravenous Anesthesia and Balanced Anesthesia on Flash Visual Evoked Potentials

Intraoperative flash visual evoked potentials (FVEPs) could monitor visual function during neurosurgery. There are fewer reports comparing the effects of sevoflurane-propofol balanced anesthesia

  • 0 views
  • 13 Mar, 2021
  • 1 location