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Found 48 clinical trials
Biomarkers in Relapsing-Remitting Multiple Sclerosis (BioMS)

Transcranial magnetic stimulation (TMS) studies reported consistent and substantial impairments in the central nervous system (CNS) in multiple sclerosis (MS). Studies of peripheral nervous system (PNS) function comprising electromyoneurography (EMNG) reported impairments of the PNS in MS that were less pronounced and inconsistent. Neurophysiological studies are generally small and cross-sectional …

immunomodulation therapy
nervous
  • 0 views
  • 12 Mar, 2022
  • 1 location
Clinical and Neuropsychological Investigations in Batten Disease

This study aims to assess the natural history of Batten disease (Neuronal Ceroid Lipofuscinosis) by obtaining information about the motor, behavioral, and functional capabilities of individuals with Batten disease. This study will also refine and validate the Unified Batten Disease Rating Scale (UBDRS) as a clinical rating instrument for Batten …

batten
ceroid lipofuscinosis
  • 143 views
  • 17 May, 2022
  • 1 location
Amyloid-β Clearance Mechanisms in Alzheimer's Disease (AmyClearAD)

The focus of this study is to examine the protein-plaque clearance (A) in relation to the blood-brain-barrier, the glymphatic system, brain lymphatic system and enzymatic degradation. In order to achieve this aim the investigators intend to study participants with a Subjective Cognitive Decline, Mild Cognitive Impairment and a mild Alzheimer's …

amyloid
dementia
alzheimer's disease
cognitive decline
mild cognitive impairment
  • 0 views
  • 25 Jan, 2022
Evaluation of the Addictive Potential of E-Cigarettes

This study will examine the subject matter from a neurobiological and a neuropsychological vantage point to ascertain whether the e-cigarette is potentially as addictive as the traditional tobacco cigarette.

  • 0 views
  • 03 Mar, 2021
  • 1 location
The Dutch Parkinson and Cognition Study (DUPARC)

Parkinson Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms. The DUPARC study is a single-centre longitudinal cohort study aimed at deeply phenotyping newly diagnosed PD patients. The main aim is to investigate the relationship between cognitive impairment and both …

Accepts healthy volunteers
neurodegenerative disorders
motor symptoms
cognitive impairment
  • 6 views
  • 19 Feb, 2022
  • 1 location
Atlas of Retinal Imaging in Alzheimer's Study (ARIAS)

The Atlas of Retinal Imaging in Alzheimer's (ARIAS) study is a 5-year study examining the natural history of retinal imaging biomarkers associated with disease risk, disease burden, and disease progression in Alzheimer's disease (AD). The objective of this project is to create a 'gold standard' reference database of structural anatomic …

eye exam
Accepts healthy volunteers
dementia
neuropsychological test
alzheimer's disease
  • 0 views
  • 25 Jan, 2022
  • 3 locations
Community-based Cohort of Functional Decline in Subjective Cognitive Complaint Elderly

Background With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in elderly, corresponding nearly to 40% of cases, and the most rapidly growing cause of death in the …

mild cognitive impairment
cognitive impairment
Accepts healthy volunteers
frontotemporal lobar degeneration
dementia
  • 3 views
  • 26 Feb, 2022
  • 1 location
EMRESERVA A Program to Enhace Cognitive Reserve in Patients With Multiple Scleorisis

Multiple Sclerosis is an immunological degenerative disease that affects the central nervous system causing cognitive impairment as one of the most disabling symptoms, in approximately 40-60% of patients. Cognitive reserve may influence the manifestation of the symptoms of cognitive impairment in MS patients and could justify interindividual differences. Cognitive reserve …

  • 0 views
  • 13 Oct, 2022