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Found 42 clinical trials
A Double-Blind, Placebo-Controlled 16-Week Study of the Cognitive Effects of the Oral P38 Alpha Kinase Inhibitor Neflamapimod in Dementia with Lewy Bodies (DLB)

The primary objective is to evaluate the effect of neflamapimod on cognitive function as assessed in a study-specific Neuropsychological Test Battery

neuropsychological test
  • 08 Dec, 2020
  • 1 location
Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients

days before surgery. Neuropsychological test battery (NPB) will be tested before intervention and at discharge for determination of Post operative cognitive dysfunction (POCD). Another group of non

  • 13 Jul, 2020
  • 13 locations
Effects of Different Types of General Anesthesia on Postoperative Pupillary Reactivity

Objective: To compare the effects of volatile and intravenous anesthetics on pupillary function after general anesthesia using a portable infrared pupillometer. Design: A monocentric, prospective, double blinded randomized study. Patients: Patients who require elective Ear, Nose and Throat (ENT) surgery under general anesthesia. Interventions: Patients undergoing elective ENT surgery will …

  • 16 Mar, 2020
  • 1 location
Effect of tDCS on Cognition Symptoms in Chronic Schizophrenia Patients With Tardive Dyskinesia

The aim of the study was to evaluate the efficacy, safety, and cognitive function of transcranial direct current stimulation (tDCS) in chronic schizophrenia patients with tardive dyskinesia (TD).

transcranial direct current stimulation
  • 08 Nov, 2020
  • 1 location
CMI-168 on Cognitive Function in Healthy Middle-aged Men and Women

The investigators propose to conduct the present study in order to primarily assess the effects of CMI-168 in neurocognition enhancement. Studies have shown that episodic memory performance is declined in elder populations showing elevated cortisol levels and cognitive decline is accelerated with greater levels of self-reporting perceived stress . Additionally, …

screening patient
cognitive decline
body mass index
  • 08 Nov, 2020
  • 1 location
Serotonergic Modulation of Cognition Emotion and Brain Activation in Healthy Volunteers

The aim of this project is: To apply a pharmacological tool of selective serotonin (5-hydroxytryptamine, 5-HT system) reuptake inhibition in healthy humans. Specifically: To investigate how sub-chronic administration of 20 mg of escitalopram affects cognitive performance ('cold' cognition) and social-emotional functioning ('hot' cognition) compared with placebo; and To investigate how …

  • 14 May, 2020
  • 1 location
Transcranial Magnetic Stimulation (TMS) for Patients With Treatment Resistant Auditory Verbal Hallucination

This study will evaluate the effect of repetitive transcranial magnetic stimulation (rTMS) in schizophrenia with treatment resistant auditory verbal hallucination

  • 08 Nov, 2020
  • 1 location
Effects of Keppra on Thinking Emotions and Balance in Elderly Healthy Volunteers

Epilepsy is a common disorder with an incidence of about 6 per 1000. The incidence progressively increases above age 50. By age 75, the incidence is two to three fold compared with any age group. Unfortunately, older individuals are especially at risk to incur significant side effects to anti-epileptic drugs. …

neuropsychological test
anti-epileptic drug
  • 07 Nov, 2020
  • 1 location
Implementation of a Cognitive Training Program to Reduce the Risk of Postoperative Cognitive Dysfunction

Background: The postoperative cognitive dysfunction (POCD) is a frequent complication, often underestimated and leads to a negative impact on the quality of life for patients and their families. Objective: Measure the effectiveness of the cognitive training in reducing POCD in patients 55 and 70 years old undergoing elective non cardiac …

cognitive impairment
heart surgery
  • 20 Jul, 2020
  • 1 location
Effects of the Transcranial Stimulation on Prevention of Cognitive Dysfunction in Cardiac Surgery

Postoperative cognitive dysfunction (POCD) is a contrary event observed between 20 to 83%, especially on elderly and patients submitted to cardiac surgery. The prevention and rehabilitation on cases of POCD can improve the quality of life and decrease the mortality in surgical patients. The effect of the noninvasive cerebral stimulation, …

brain injury
cognitive impairment
heart surgery
  • 16 Jul, 2020
  • 1 location