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Found 35 clinical trials
Featured trial
  • 122 views
  • 08 Dec, 2020
  • 1 location
Temelimab as a Disease Modifying Therapy in Patients With Neurological, Neuropsychological, and Psychiatric (=Neuropsychiatric) Symptoms in Post-COVID 19 or Postacute Sequelae of COVID-19 (PASC) Syndrome

This study is a Phase 2, 24-week, randomized, prospective, double-blind, multicenter study in patients experiencing neuropsychiatric symptoms and functional impairment in the course of PASC. The

  • 0 views
  • 24 Oct, 2022
  • 2 locations
Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach

, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation

Accepts healthy volunteers
  • 206 views
  • 15 Feb, 2022
  • 1 location
SOLIDARITY Finland Long-COVID (Remdesivir Long-term Follow-up Study of COVID Patients)

SOLIDARITY Finland Long-COVID trial assesses the effects of remdesivir + standard of care (SoC) vs. only SoC on long-COVID symptoms and quality of life (QoL) using questionnaires at one and two years post-discharge. Objectives i) Long-COVID symptoms To investigate the effect of remdesivir (vs. SoC) on the occurrence of symptoms …

  • 0 views
  • 04 Oct, 2022
  • 1 location
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Assess the Efficacy and Safety of JNJ-63733657, an Anti-tau Monoclonal Antibody, in Participants With Early Alzheimer's Disease (Autonomy)

The primary purpose of this study is to evaluate the effect of JNJ-63733657 versus placebo on clinical decline as measured by the Integrated Alzheimer's Disease Rating Scale (iADRS), a composite of cognition and function.

cognitive assessment
alzheimer's disease
cognitive decline
dementia
  • 72 views
  • 21 Oct, 2022
  • 102 locations
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, 52-week Study Evaluating the Safety and Efficacy of Simufilam 100 mg Tablets in Subjects With Mild-to-Moderate Alzheimer's Disease (RETHINK-ALZ)

A 52-week safety and efficacy study of simufilam (PTI-125) given twice daily to participants with mild-to-moderate Alzheimer's disease (AD) for 52 weeks. Approximately 750 participants will be randomized (1:1) to receive either placebo or 100 mg tablets of simufilam, twice daily, for 52 weeks. Clinic visits will occur 4 weeks …

alzheimer's disease
dementia
mini-mental state examination
  • 697 views
  • 10 Oct, 2022
  • 73 locations
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, 76-week Study Evaluating the Safety and Efficacy of Two Doses of Simufilam in Subjects With Mild-to-Moderate Alzheimer's Disease (REFOCUS-ALZ)

A 76-week safety and efficacy study of simufilam (PTI-125) given twice daily to participants with mild-to-moderate Alzheimer's disease (AD) for 76 weeks. Approximately 1083 participants will be randomized (1:1:1) to receive either placebo, 50 mg tablets of simufilam, or 100 mg tablets of simufilam, twice daily, for 76 weeks. Clinic …

alzheimer's disease
dementia
mini-mental state examination
  • 18 views
  • 15 Oct, 2022
  • 64 locations
MEMORI Corps: A Novel Activity-based Companion Care Program to Benefit Community-living Persons With Dementia, Their Families, and Senior Volunteers (MEMORI Corps)

This is a single blind, intention-to-treat, randomized controlled trial design to evaluate the feasibility and efficacy of a 12-week, evidence-based, individualized MEMORI Corps program delivered by trained older volunteers (n=80) to community-living PWD/CG dyads (n=240). Eligible PWD/CG dyads will be randomized to receive 12-weeks intervention group (n=120), or 12-week augmented …

Accepts healthy volunteers
mental state examination
mini-mental state examination
dementia
  • 6 views
  • 22 Oct, 2022
  • 1 location
Exploring Mechanisms for Neuropsychiatric Symptoms of Parkinson Disease Using Transcranial Direct Current Stimulation

This study evaluates the effect of transcranial direct current stimulation (tDCS) on non-motor symptoms of Parkinson's disease, including depression and cognitive symptoms. Participants are randomized to receive active or sham tDCS for 30 minutes over 10 treatment sessions.

brain stimulation
depressed mood
motor symptoms
depression
movement disorder
  • 3 views
  • 20 Apr, 2022
  • 1 location
Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS (tTED)

Agitation and aggression impose a tremendous burden on the individuals living with dementia, their families, caregivers, and healthcare systems. Neuropsychiatric symptoms of dementia (NPS

agitation
neurological disorder
alzheimer's disease
anesthesia
Accepts healthy volunteers
  • 8 views
  • 06 Feb, 2022
  • 1 location