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Found 207 clinical trials
Effects of Neuromodulation in Laryngeal Dystonia

neuromodulation technique, in assessing cortical excitability and inhibition of laryngeal musculature. Previous work conducted by the investigator has demonstrated decreased intracortical inhibition in those with

Accepts healthy volunteers
  • 27 Apr, 2022
  • 1 location
Neuromodulation of Inflammation and Endothelial Function

Heart failure with reduced ejection fraction (HFrEF) is a major cause of mortality in United States. Aging is a major risk factor for adverse outcomes associated with HFrEF, with majority of the patient's over the age of 50, continuing to experience symptoms, reduced exercise capacity and poor quality of life. …

diastolic dysfunction
chronic heart failure
systolic heart failure
ejection fraction
  • 27 May, 2022
  • 1 location
Neuromodulation and Neurorehabilitation for mTBI Plus PTSD

This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation (iTBS), a type of repetitive transcranial magnetic stimulation and (ii) determine how APT + iTBS changes the neurocognitive system of …

transcranial magnetic stimulation
cognitive training
post-traumatic stress disorder
  • 13 Feb, 2022
  • 2 locations
Sacral Neuromodulation as Treatment for Fecal Incontinence (LLLT-FI)

The objective of this study is to investigate if low level laser therapy will do more good than harm for patients with severe refractory fecal incontinence. It is a proof of concept study without a placebo arm.

  • 27 Apr, 2022
  • 1 location
Sacral Neuromodulation as Treatment for Chronic Constipation

The objective of this study is to study if low level laser therapy will do more good than harm for patients with severe chronic refractory constipation. It is a proof of concept study without a placebo arm.

  • 26 Apr, 2022
  • 1 location
Cardiac Neuromodulation Therapy (CNT) "Washout" Sub-Study

This washout protocol is structured as a sub-study for patients willing to participate after finishing the double blind randomised phase of the clinical trial, NCT02837445. Devices will be turned off for a week approximately. Patients will have their PHC programmed to automatically turn off 24 hr after a medical and …

  • 25 Mar, 2022
  • 1 location
Individually Targeted Neuromodulation for Contamination-based OCD

Patients with obsessive-compulsive disorder (OCD) experience a wide array of different types of obsessions and compulsions. However, current treatments for OCD employ a "one size fits all" approach and are used for all patients regardless of symptom type. In this project, the investigators propose to investigate whether a novel method …

  • 13 Jul, 2022
  • 1 location
Evaluation of Implantable Tibial Neuromodulation Pivotal Study (TITAN 2)

The purpose of this prospective, multicenter study is to assess the safety and efficacy of tibial neuromodulation using the Medtronic Tibial Neuromodulation (TNM) system.

conservative therapy
  • 09 Aug, 2022
  • 19 locations
Dorsomedial Prefrontal Neuromodulation in Treatment-resistant Depression

Major depressive disorder (MDD) is a common and troublesome disorder, with high risk of physical and psychiatric comorbidity. At least one-third of patients could not achieve a response after several antidepressant trials, so-called treatment-refractory depression (TRD). The high-frequency repetitive transcranial magnetic stimulation (rTMS) or intermittent theta-burst stimulation (iTBS) at left-sided …

  • 04 Oct, 2022
  • 1 location
Neuromodulation and Cognitive Training in Opioid Use Disorder

The relapsing nature of opioid use disorder is a major obstacle to successful treatment. About 90% of those entering treatment will relapse within one year. To improve treatment outcome, new interventions targeting the underlying brain biomarkers of relapse vulnerability hold significant promise in reducing this critical public health problem. Transcranial …

substance use
opioid use disorder
opioid use
mental illness
  • 15 Feb, 2022
  • 1 location