Found 375 clinical trials
Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity (LIFUS-Pharma)
resolution than other brain stimulation tools. Its use as a potential clinical tool for treatment of neurological disorders is reliant on an understanding of its mechanisms of action. Although it has been
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- 08 Jun, 2022
- 1 location
The Role of Meningeal Lymphatic Vessels in the Absorption of Chronic Subdural Hematoma and Its Injury Mechanism
such as Alzheimer's disease (AD), traumatic brain injury (TBI), and subarachnoid hemorrhage (SAH). This phenomenon suggests that mLVs play an important role in central nervous system diseases.
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- 07 Jul, 2022
- 1 location
A Phase I Tolerability, Safety, Pharmacokinetics and Preliminary Efficacy Study of Oral Monepantel in Individuals With Motor Neurone Disease
Amyotrophic lateral sclerosis/ Motor Neurone Disease (ALS/MND) is a rare and invariably fatal neurological disease. ALS/MND has a terribly high burden on patients, family and carers, and carries
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- 28 Oct, 2022
- 2 locations
Research on an Electronic APP to Improve the Oral Biomechanics of Hong Kong Elderly (HOE)
Hong Kong and Japan are similar in terms of facing the super-ageing society. Maintaining oral function in elderly is particularly important because it affects social, physical and mental health to the people and to the society. By using technology seems to be one of the solutions in dealing with this. …
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- 29 Oct, 2022
- 1 location
Brain-Computer Interfaces in Laryngeal Dystonia
The researchers will develop and evaluate the use of adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystonia.
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- 04 Oct, 2022
- 1 location
Safety and Efficacy of Esmketamine Versus Dexmedetomidine
A comparative study on the safety and efficacy of esmketamine versus Dexmedetomidine during drug induced sleep endoscopy in children with positional obstructive sleep apnea: A consort-prospective, randomized, controlled clinical trial
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- 04 Oct, 2022
- 1 location
Brain State-dependent Stimulation to Improve Movement (BrainSTIM)
Repetitive transcranial magnetic stimulation (rTMS) is a powerful tool to non-invasively modulate brain circuits, brain plasticity, and behavior. This proposal will test the hypothesis that controlling behavioral state during focal multi-day rTMS of a brain region involved in grasping movements will enhance the functional specificity of the neuromodulation action among …
- 2 views
- 06 Apr, 2022
- 1 location
A Phase 1a/1b Trial of Intrathecal Deferoxamine for Leptomeningeal Metastases
The researchers are doing this study to find out whether deferoxamine (DFO) given intrathecally (directly into the CSF) is a safe treatment for people with leptomeningeal metastasis from solid tumor cancer. The researchers will test different doses of DFO to find the highest dose that causes few or mild side …
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- 16 Oct, 2022
- 7 locations
Repeated Oscillatory TMS Therapy of the Epileptogenic Cortical Area in Children With Focal CSWS
The investigators are investigating the effectiveness of a wearable multisite transcranial magnetic stimulation (mTMS) device that can deliver stimuli at multiple cortical sites simultaneously or sequentially for the treatment of an epileptic syndrome - focal continuous-spike and wave during sleep.
- 10 views
- 13 Jun, 2022
- 1 location
Sensorimotor Imaging for Brain-Computer Interfaces
The investigators will use fMRI to map movement activity in motor and somatosensory cortex using enriched imagery in people with chronic tetraplegia. The investigators expect that somatotopic organization of movement activity will be preserved in people with upper limb impairments, which can be quantified using the strength, area, and location …
- 0 views
- 05 May, 2022
- 1 location