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Found 32 clinical trials
Oxybutynin for Post-surgical Bladder Pain and Urgency

Bladder pain and urgency are common after bladder surgery. The objective is to determine if transdermal administration is superior to oral administration in alleviating pain and urgency.

bladder surgery
oxybutynin
  • 3 views
  • 25 Mar, 2022
  • 1 location
Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury

, participants will either receive an implanted nerve stimulator (like a pace-maker for the bladder) or standard care for neurogenic bladder. Patients will be assigned to one of these groups at random and

sacral nerve stimulation
neurogenic bladder
spinal cord
implant device
incomplete spinal cord injury
  • 99 views
  • 03 Mar, 2022
  • 4 locations
A Two-part, Multicenter, Dose-titration Study Evaluating Efficacy, Safety, Pharmacodynamics and Pharmacokinetics of Oxybutynin Chloride 10% Gel for Treatment of Detrusor Overactivity Associated Neurological Condition in Pediatric Patients

This study will evaluate the safety and efficacy of Oxybutynin Chloride 10% Topical Gel in children 3 to less than 17 years old, who have overactive bladder due to a neurogenic condition. Children will be treated with 0.75 g of gel/day for two weeks. Patients will then return to the …

overactive bladder
oxybutynin
neurogenic bladder
  • 96 views
  • 18 Oct, 2022
  • 5 locations
Intravesical Lactobacillus rhamnosusGG Versus Saline Bladder Wash: A Randomized, Controlled, Comparative Effectiveness Clinical Trial

This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI).

antibiotics
  • 0 views
  • 19 Oct, 2022
  • 1 location
Motor and Autonomic Concomitant Health Improvements With Neuromodulation and Exoskeleton Training: A RCT in Individuals With SCI (MACHINE)

Spinal cord injury (SCI) disrupts many aspects of life, including the loss of volitional movement and involuntary control of bodily functions; both crucial functional recovery priorities for this population. Mobility impairments and secondary complications limit an individual's ability to exercise, a behavior known to have wide-ranging functional and health benefits. …

spinal cord disorder
spinal cord
gait training
spinal cord stimulation
  • 0 views
  • 13 Jun, 2022
  • 1 location
Recovery of Bladder and Sexual Function After Human Spinal Cord Injury

This study will incorporate critical cross viscero-visceral intersystem interactions to 1) investigate in a controlled laboratory setting and then with mobile at-home monitoring the extent, severity, and frequency of occurrence of autonomic dysreflexia with respect to daily bladder and bowel function, in conjunction with identifying potential underlying mechanisms by examining …

autonomic dysreflexia
spinal cord disorder
neurogenic bladder
  • 6 views
  • 26 May, 2022
  • 1 location
Intravesical Lactobacillus to Reduce Urinary Symptoms After Spinal Cord Injury

The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG®) dose to be used …

spinal cord disorder
urinary symptoms
neurogenic bladder
spinal cord
intermittent catheterization
  • 42 views
  • 11 Oct, 2022
  • 1 location
Below the Belt: Non-invasive Neuromodulation to Treat Bladder, Bowel, and Sexual Dysfunction Following Spinal Cord Injury

Recent findings have demonstrated that electrical stimulation to the spinal cord (i.e. implanted electrodes) can significantly recover bladder, bowel, and sexual function after injury. While promising, a major drawback is that individuals must undergo a highly invasive and expensive surgical procedure to implant the stimulator on top of the spinal …

spinal cord disorder
spinal cord
electrical stimulation
spinal cord stimulation
  • 0 views
  • 02 Jun, 2022
  • 1 location
Electrical Stimulation for Continence After Spinal Cord Injury

This study aims to improve continence and voiding of patients with spinal cord injury using electrical stimulation. The Finetech Vocare Bladder System is an implantable sacral nerve stimulator for improving bladder and bowel function in patients with spinal cord injury (SCI). It has been commercially available in Britain and other …

urodynamic studies
stress incontinence
spinal cord disorder
nervous
incontinence
  • 272 views
  • 09 May, 2022
  • 4 locations
Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction

An investigator initiated pilot study: two arm, double blind, placebo controlled, randomized, group of approximately 60 patients with spinal cord injury, and who have evidence of neurogenic

spinal cord disorder
spinal cord
neurogenic bladder
  • 0 views
  • 22 Mar, 2022
  • 1 location