Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 571 clinical trials
An Open-Label, Multiple-Dose, Dose-Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of VMD-928 in Subjects With Solid Tumors or Lymphoma

This is a multicenter, open-label, Phase 1 study of orally administered VMD-928 in adult subjects with advanced solid tumors or lymphoma that have progressed or are non responsive to available therapies and for which no standard or available curative therapy exists

myeloid leukemia
esophageal cancer
cancer chemotherapy
carcinoma
lymphoma
  • 92 views
  • 25 Oct, 2022
  • 7 locations
A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of KY1044 as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies

A Phase 1/2, open label, multi-center study to evaluate the safety, efficacy and tolerability of KY1044 as single agent and in combination with anti-PD-L1 (atezolizumab) in adult patients with selected advanced malignancies, who are ineligible for or there are no available therapies known to confer a clinical benefit for their …

triple negative breast cancer
lung carcinoma
atezolizumab
measurable disease
squamous cell carcinoma of head and neck
  • 101 views
  • 18 Oct, 2022
  • 10 locations
A Phase 1/2 Dose Escalation/Expansion Study of NGM707 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

Study of NGM707 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

pembrolizumab
  • 0 views
  • 17 Oct, 2022
  • 15 locations
HMBD-001 in Advanced HER3 Positive Solid Tumours

This clinical trial is evaluating a drug called HMBD-001 (an anti-HER3 monoclonal antibody) in patients with advanced HER3 positive solid tumours. The main aims are to find out the maximum dose of HMBD-001 that can be given safely to patients alone and in combination with other anti-cancer agents, more about …

pancreatic cancers
carcinoma
bladder tumor
antineoplastic
immunohistochemistry
  • 0 views
  • 20 Dec, 2021
  • 2 locations
A Phase 2 Basket Study of the Oral TRK Inhibitor Larotrectinib in Subjects With NTRK Fusion-positive Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

NTRK
lung cancer
breast cancer
tyrosine
lung carcinoma
  • 163 views
  • 21 Oct, 2022
  • 125 locations
Liquid Biopsy Evaluation and Repository Development at Princess Margaret (LIBERATE)

The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the University Health Network's Princess Margaret Cancer Centre. Circulating cell-free nucleic acids (cfNA), including cell-free DNA (cfDNA) and …

solid tumor
cancer diagnosis
cfdna
tumor progression
Accepts healthy volunteers
  • 171 views
  • 05 May, 2022
  • 1 location
Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies

This is a phase I/II, non randomized, open-label, dose escalation study to investigate the safety, tolerability and preliminary efficacy of CB-103.

anaplastic large cell lymphoma
serum bilirubin level
t-cell lymphoma
sarcoma
metastasis
  • 286 views
  • 25 Mar, 2022
  • 15 locations
A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) (DUET-3)

This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors.

erbb2
urothelial carcinoma
measurable disease
sarcoma
endometrial carcinoma
  • 139 views
  • 06 Feb, 2022
  • 13 locations
The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors

The purpose of this prospective, interventional, single-arm pilot study is to evaluate whether virtually delivered group-based physical activity is feasible for adolescent and young adult (AYA) cancer survivors. AYAs who were diagnosed with cancer and have completed cancer treatment will be recruited for this study. This study will enroll 20 …

cancer treatment
primary cancer
Accepts healthy volunteers
cancer
  • 0 views
  • 12 Mar, 2022
  • 1 location
Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to Drugs

The primary objective of this study, sponsored by Travera LLC in Massachusetts, is to validate whether the mass response biomarker has potential to predict response of patients to specific therapies or therapeutic combinations using isolated tumor cells from varying cancers and biopsy formats. Cohorts include patients with stage III or …

lung cancer
breast cancer
carcinoma
cancer
lung carcinoma
  • 0 views
  • 20 Oct, 2022
  • 1 location