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Found 137 clinical trials
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Randomized Trial of Topotecan With M6620 an ATR Kinase Inhibitor in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs

This phase II trial studies how well M6620 works when given in combination with topotecan hydrochloride (topotecan) compared with topotecan alone in treating patients with small cell lung cancer that has come back (relapsed), or small cell cancer that arises from a site other than the lung (extrapulmonary). Drugs used …

therapeutic agents
antiretroviral therapy
brain metastases
topotecan
neutrophil count
  • 4 views
  • 14 Nov, 2021
  • 17 locations
None
TiTAN-1: Safety Proliferation and Persistence of GEN-011 Autologous Cell Therapy

TiTAN-1 is a first-in-human study of GEN-011, an experimental treatment being evaluated in adult patients with advanced cancer. GEN-011 is a T cell therapy made specific to each patient, using the patient's own circulating immune cells. First, Genocea confirms which cancer proteins are recognized already by each patient's T cells …

urothelial carcinoma
fludarabine
interleukin 2
lung carcinoma
carcinoma
  • 0 views
  • 26 Nov, 2021
  • 8 locations
None
Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors

This research study is studying a combination of drugs as a possible treatment for rare genitourinary malignancies among four cohorts, bladder or upper tract carcinoma with variant histology, adrenocortical carcinoma, other rare genitourinary carcinomas and any genitourinary carcinoma with neuroendocrine differentiation. Given preliminary results, the study is being tested in …

hysterectomy
carcinoma
neutrophil count
bilateral oophorectomy
cancer
  • 81 views
  • 17 Jul, 2021
  • 6 locations
None
Cabazitaxel Carboplatin and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer

This phase II trial studies the effect of cabazitaxel, carboplatin, and cetrelimab followed by niraparib with or without cetrelimab in treating patients with aggressive variant prostate cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as cabazitaxel and carboplatin, work in different ways to stop …

  • 0 views
  • 03 Feb, 2021
  • 1 location
None
Human Milk Fortification in Extremely Preterm Infants

is not blinded. Primary endpoint of the intervention is the composite variable necrotizing enterocolitis (NEC), sepsis and mortality. The enrolled infants are characterised with

parenteral nutrition
enteral feeding
human breast milk
antibiotics
sepsis
  • 1 views
  • 01 Dec, 2021
  • 8 locations
None
Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors

This study evaluates whether it is safe to Focused Ultrasound Ablation (FUSA) treatments with and without PD-1 blockade and with and without imiquimod. A device called the Echopulse will be used for the FUSA therapy. Patients will be assigned to 1 of 2 cohorts depending on their disease and treatment …

solid tumour
pd-l1
solid tumor
solid tumors
residual tumor
  • 4 views
  • 20 Aug, 2021
  • 1 location
None
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

This is a Phase 2 study to evaluate the efficacy of a non-myeloablative lymphodepleting preparative regimen followed by infusion of autologous TIL and high-dose aldesleukin in patients with locally advanced, recurrent, or metastatic cancer associated with one of the following cancer types: 1.) gastric/esophagogastric, 2.) colorectal, 3.) pancreatic, 4.) sarcoma, …

filgrastim
gilbert's syndrome
alt/ast
neutrophil count
platelet count
  • 12 views
  • 07 Apr, 2021
  • 1 location
None
LITT and Pembrolizumab in Recurrent Brain Metastasis

This is an open-label, historically controlled pilot study investigating the immune effect of Laser Interstitial ThermotHerapy (LITT)+ pembrolizumab in adult patients with a primary cancer approved by the FDA for treatment with an immune-checkpoint inhibitor who have recurrent brain metastasis after prior stereotactic radiosurgery (SRS).

pembrolizumab
direct bilirubin
carcinoma
squamous cell carcinoma
probe
  • 0 views
  • 21 Aug, 2021
  • 1 location
None
Safety Tolerability Pharmacokinetics and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of INCB099318 in select solid tumors.

  • 0 views
  • 06 Aug, 2021
  • 3 locations
None
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that have spread to other places in the body. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. …

rifampin
carcinoma
neutrophil count
platelet count
amylase
  • 193 views
  • 05 Dec, 2021
  • 478 locations