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Found 470 clinical trials
Improving Access to Child Anxiety Treatment (IMPACT)

There is strong evidence that cognitive behavioral therapy (CBT) with exposure is the preferred treatment for youth with anxiety disorders, but outpatient services that provide this type of treatment are limited. Even for those who do have access to anxiety-specific treatment, a traditional outpatient model of treatment delivery may not …

anxiety disorder
behavioral therapy
cognitive therapy
anxiety treatment
  • 15 Mar, 2022
  • 1 location
Neonatal Seizure Registry - Developmental Functional EValuation (NSR-DEV)

The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for developmental disabilities and whether these are modified by parent well-being.

developmental disabilities
neonatal convulsions
neonatal seizures
  • 04 Mar, 2022
  • 7 locations
Study of Proteus Syndrome and Related Congenital Disorders

This study will examine rare congenital disorders that involve malformations and abnormal growth. It will focus on patients with Proteus syndrome, whose physical features are characterized by overgrowth, benign tumors of fatty tissue or blood vessels, asymmetric arms or legs, and large feet with very thick soles. The study will …

  • 16 Jun, 2022
  • 1 location
Cognitive Remediation in Forensic Mental Health Care (CRFMHC)

Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation. One empirically-validated method to train executive functions is cognitive remediation, which consists of cognitive exercises combined with coaching. This trial investigates whether cognitive remediation can improve cognitive, functional, and clinical …

cognitive deficits
cognitive remediation
  • 16 Jun, 2022
  • 1 location
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (POPS or POP02)

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to …

Accepts healthy volunteers
  • 04 Mar, 2022
  • 43 locations
Safety and Efficacy of Fecal Microbiota Transplantation

The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease states. Fecal microbiota transplantation (FMT), defined as infusion of feces from healthy donors …

resistant infection
metabolic syndrome
  • 23 Mar, 2022
  • 1 location
Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study (ACIST)

The purpose of the study is to evaluate the use of autologous Bone Marrow Derived Stem Cells (BMSC) as a means to improve cognitive impairment as occurs in Alzheimer's Disease and other dementias and to improve behavior and socialization issues which occur in adult Autism Spectrum Disorder. The use of …

medical therapy
alzheimer's disease
cognitive impairment
pervasive developmental disorder
  • 27 Apr, 2022
  • 3 locations
A Trial of Metformin in Individuals With Fragile X Syndrome (Met)

This study is a controlled trial of metformin in individuals with fragile X syndrome between the ages of 6 and 35 years. Participants will be randomized in a double-blind design to either drug or placebo and will attend three visits to the study site in a 4-month period for a …

problem behavior
  • 11 Feb, 2022
  • 1 location
Dopaminergic Therapy for Frontotemporal Dementia Patients

This is a phase IIa 24-week randomized, double-blind, placebo-controlled study. The study is designed to evaluate the efficacy and safety of Rotigotine (RTG) transdermal administration at the dosage of 4 mg or 6 mg per day versus Placebo (PLC) in newly diagnosed behavioural Frontotemporal Dementia (bvFTD) patients. 75 patients with …

dementia, frontotemporal
acetylcholinesterase inhibitor
  • 25 Jan, 2022
  • 3 locations
Study of Selected X-Linked Disorders: Aicardi Syndrome

Based on our current understanding of Aicardi syndrome, the condition is hypothesized to occur due to a genetic change on the X-chromosome. The research team is investigating Aicardi syndrome to identify the specific gene location associated with the disorder. Th investigators are collecting blood and skin biopsy samples from patients …

  • 03 May, 2022
  • 1 location