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Found 1514 clinical trials
Pilot Phase 1 Clinical Trial of PET Scanning in Tau Protein Deposition and Connectome Analysis in Traumatic Encephalopathy Syndrome (TES) Cohort With a Probable Chronic Traumatic Encephalopathy (CTE) Pattern of Neurodegenerative Disease (TACIT)

This pilot study aims to assess if participants that meet the criteria for a TES diagnosis have a specific tau deposition profile on PET scanning using the PET tau binding ligand - [18F] PI-2620. It is hoped this study will highlight potential diagnostic tests of TES diagnosis, the in-life correlate …

stroke
neuropsychological assessment
  • 0 views
  • 18 Sep, 2022
  • 1 location
Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disease affecting the motor neuron. Currently, there is no diagnostic test and no examination that can predict the

Accepts healthy volunteers
primary lateral sclerosis
  • 0 views
  • 18 Oct, 2021
Non-invasive Brain Stimulation for the Treatment of Depression Symptoms in ALS

Sclerosis (ALS) and other neurodegenerative disorders.

benzodiazepines
degenerative disorder
primary lateral sclerosis
motor neuron disease
neurodegenerative disorders
  • 51 views
  • 25 Apr, 2022
  • 1 location
Randomized Double-blind Safety and Efficacy of Recombinant Human Erythropoietin in Amyotrophic Lateral Sclerosis

Erythropoietin is neuroprotective in animal models of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The aim of this study was to determine the safety and feasibility

  • 0 views
  • 22 Jan, 2021
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire)

The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, in pediatric participants with Canavan disease.

  • 0 views
  • 25 Apr, 2022
Pre-Active PD: Looking at Physical Activity Behavior Change in Parkinson's Disease

structure of the intervention is based on previous research in neurodegenerative disease including Parkinson's disease and Huntington's disease.

huntington's disease
  • 0 views
  • 13 May, 2022
  • 2 locations
Insulin Resistance in Multiple System Atrophy (IRAMS)

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder. The pathologic hallmark is the accumulation of aggregated alpha-synuclein in oligodendrocytes forming glial

insulin resistance
Accepts healthy volunteers
insulin
alpha-synuclein
  • 3 views
  • 23 Apr, 2022
  • 1 location
Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease

This study is a multicenter randomized double-blind placebo-controlled study. The research content is 1. The improvement effect of Bifidobacterium triple viable capsulesBIFICO on motor symptoms and constipation and sleep in mild to moderate Parkinson's disease and the safety of the study; 2. the mechanism of the improvement effect of intestinal …

Accepts healthy volunteers
parkinson's disease
constipation
benserazide
levodopa
  • 0 views
  • 25 Jan, 2022
  • 1 location
Promoting Physical Activity Engagement for People With Early-mid Stage Parkinson's Disease (Engage-PD) (Engage-PD)

uptake as part of an effective self-management program. The structure of the coaching program is based on previous research in neurodegenerative disease including Parkinson's disease and Huntington's

aerobic exercise
huntington's disease
  • 0 views
  • 25 Jan, 2022
  • 1 location
Amyloid-beta PET Imaging With 18F-92 in Alzheimer's Disease

Alzheimer's disease is a neurodegenerative disease. Numerous studies have reported that β-amyloid (Aβ) is an important marker for the diagnosis of AD. 18F-92 molecular probe is a novel

Accepts healthy volunteers
memory impairment
amyloid
alzheimer's disease
  • 0 views
  • 24 Jan, 2022
  • 1 location